Department of Structural Biology, Medical University of Lodz, 90-419 Lodz, Poland.
Biomolecules. 2023 Sep 17;13(9):1402. doi: 10.3390/biom13091402.
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycaemia and oxidative stress. Oxidative stress plays a crucial role in the development and progression of diabetes and its complications. Nutritional antioxidants derived from dietary sources have gained significant attention due to their potential to improve antidiabetic therapy. This review will delve into the world of polyphenols, investigating their origins in plants, metabolism in the human body, and relevance to the antioxidant mechanism in the context of improving antidiabetic therapy by attenuating oxidative stress, improving insulin sensitivity, and preserving β-cell function. The potential mechanisms of, clinical evidence for, and future perspectives on nutritional antioxidants as adjuvant therapy in diabetes management are discussed.
糖尿病是一种以高血糖和氧化应激为特征的慢性代谢性疾病。氧化应激在糖尿病及其并发症的发生和发展中起着至关重要的作用。来源于膳食的营养抗氧化剂因其改善抗糖尿病治疗的潜力而受到广泛关注。本综述将深入探讨多酚的世界，研究其在植物中的来源、在人体中的代谢以及在改善抗糖尿病治疗方面的相关性，通过减轻氧化应激、提高胰岛素敏感性和保护β细胞功能来改善抗氧化机制。讨论了营养抗氧化剂作为糖尿病管理辅助治疗的潜在机制、临床证据和未来展望。
