Ahmed Munsur, Tomlin Stephen, Tuleu Catherine, Garfield Sara
Pharmacy Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
School of Pharmacy, University College London, London WC1N 1AX, UK.
Pharmaceutics. 2024 Sep 14;16(9):1212. doi: 10.3390/pharmaceutics16091212.
Personalised medicine, facilitated by advancements like 3D printing, may offer promise in oncology. This scoping review aims to explore the applicability of 3D printing for personalised pharmaceutical dosage forms in paediatric cancer care, focusing on treatment outcomes and patient experiences. Following the Joanna Briggs Institute (JBI) methodology, a comprehensive search strategy was implemented to identify the relevant literature across databases including PubMed, Embase, and Web of Science. Three independent reviewers conducted study selection and data extraction, focusing on studies involving paediatric patients under 18 years old and pharmaceutical dosage forms manufactured using 3D printing technology. From 2752 records screened, only six studies met the inclusion criteria, none of which specifically targeted paediatric cancer patients. These studies examined aspects of acceptability, including swallowability, taste, and feasibility of 3D-printed formulations for children. While the studies demonstrated the potential benefits of 3D printing in paediatric medication, particularly in personalised dosing, there is a notable lack of evidence addressing its acceptability in paediatric cancer patients. Further interdisciplinary collaborative research is needed in this area to fully assess preferences and acceptability among children with cancer and their parents or caregivers.
由3D打印等技术进步推动的个性化医疗，可能在肿瘤学领域带来希望。本综述旨在探讨3D打印在儿科癌症护理中用于个性化药物剂型的适用性，重点关注治疗效果和患者体验。遵循乔安娜·布里格斯研究所（JBI）的方法，实施了全面的检索策略，以识别包括PubMed、Embase和Web of Science在内的数据库中的相关文献。三名独立评审员进行了研究筛选和数据提取，重点关注涉及18岁以下儿科患者以及使用3D打印技术制造的药物剂型的研究。在筛选的2752条记录中，只有六项研究符合纳入标准，且均未专门针对儿科癌症患者。这些研究考察了可接受性的各个方面, 包括儿童对3D打印制剂的吞咽性、味道和可行性。虽然这些研究证明了3D打印在儿科用药方面的潜在益处，特别是在个性化给药方面，但明显缺乏关于其在儿科癌症患者中可接受性的证据。该领域需要进一步开展跨学科合作研究，以全面评估癌症患儿及其父母或照顾者的偏好和可接受性。
