Ianno Veronica, Vurpillot Sarah, Prillieux Sylvain, Espeau Philippe
CNRS, INSERM, Chemical and Biological Technologies for Health Group (UTCBS), Université Paris Cité, 75006 Paris, France.
Delpharm Reims, 51100 Reims, France.
Pharmaceutics. 2024 Mar 22;16(4):441. doi: 10.3390/pharmaceutics16040441.
Three-dimensional printing (3DP) technology in pharmaceutical areas is leading to a significant change in controlled drug delivery and pharmaceutical product development. Pharmaceutical industries and academics are becoming increasingly interested in this innovative technology due to its inherent inexpensiveness and rapid prototyping. The 3DP process could be established in the pharmaceutical industry to replace conventional large-scale manufacturing processes, particularly useful for personalizing pediatric drugs. For instance, shape, size, dosage, drug release and multi-drug combinations can be tailored according to the patient's needs. Pediatric drug development has a significant global impact due to the growing needs for accessible age-appropriate pediatric medicines and for acceptable drug products to ensure adherence to the prescribed treatment. Three-dimensional printing offers several significant advantages for clinical pharmaceutical drug development, such as the ability to personalize medicines, speed up drug manufacturing timelines and provide on-demand drugs in hospitals and pharmacies. The aim of this article is to highlight the benefits of extrusion-based 3D printing technology. The future potential of 3DP in pharmaceuticals has been widely shown in the last few years. This article summarizes the discoveries about pediatric pharmaceutical formulations which have been developed with extrusion-based technologies.
制药领域的三维打印（3DP）技术正在给控释药物递送和药品开发带来重大变革。由于其固有的低成本和快速成型特点，制药行业和学术界对这项创新技术的兴趣日益浓厚。3DP工艺可在制药行业中建立起来，以取代传统的大规模制造工艺，这对儿科药物的个性化定制尤为有用。例如，形状、尺寸、剂量、药物释放和多药组合都可以根据患者的需求进行定制。由于对可获取的适合儿童年龄的儿科药物以及可接受的药品以确保患者坚持规定治疗的需求不断增加，儿科药物开发在全球具有重大影响。三维打印为临床药物开发提供了几个显著优势，比如能够实现药物个性化、加快药物生产时间表以及在医院和药房按需提供药物。本文旨在突出基于挤出的3D打印技术的优势。在过去几年中，3DP在制药领域的未来潜力已得到广泛展现。本文总结了利用基于挤出的技术开发儿科药物制剂的相关发现。
