Sokova O I, Kulagina O E, Solov'ev Iu N, Pogosiants E E
Eksp Onkol. 1985;7(5):15-7.
Sensitivity of normal gray and mutant beige (pink-eyed dilution mutation) Djungarian hamsters to the carcinogenic activity of 7,12-dimethylbenz (a) anthracene (DMBA) and 3-methylcholanthrene (MC) was studied. No differences between these two groups of animals which were given pills with DMBA were revealed. At the same time the beige females were found to be more sensitive to MC than males and hamsters of wild (gray) colour. Among tumours induced both by DMBA and MC fibrosarcomas prevailed both in the gray and beige hamsters. Fibrous histiocytomas were detected only in the MC-infected hamsters. Epithelial tumours were found only in females.
研究了正常灰色和突变米色(粉红眼稀释突变)的西伯利亚仓鼠对7,12 - 二甲基苯并(a)蒽(DMBA)和3 - 甲基胆蒽(MC)致癌活性的敏感性。给这两组动物投喂含DMBA的药丸后,未发现它们之间存在差异。同时发现,米色雌性仓鼠比雄性以及野生(灰色)仓鼠对MC更敏感。在由DMBA和MC诱导产生的肿瘤中,纤维肉瘤在灰色和米色仓鼠中均占主导。仅在感染MC的仓鼠中检测到纤维组织细胞瘤。上皮肿瘤仅在雌性中发现。