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[利用巨大芽孢杆菌H的亚细胞成分对3-甲基胆蒽诱导的BALB/c小鼠成瘤作用的修饰]

[Modification of 3-methylcholanthrene-induced blastomogenesis in BALB/c mice by using the subcellular components of Bac. megaterium H].

作者信息

Zatula D G, Lisovenko G S, Siadro T A

出版信息

Eksp Onkol. 1985;7(5):18-20.

PMID:3933948
Abstract

It is shown that the cytoplasm of Bac. megaterium H possessing the antigenic affinity with the malignant tumour cells, being injected 7 days before the 3-methylcholanthrene injection promotes intensification of its blastomogenic effect, reduces both the period of tumour appearance and longevity of the tumour-bearing animals. On the contrary the cell wall preparation under the similar conditions, produces a therapeutic effect. An assumption is advanced that the effect of these preparations is associated with their different influence on the immune system.

摘要

结果表明,在注射3-甲基胆蒽前7天注射与恶性肿瘤细胞具有抗原亲和力的巨大芽孢杆菌H的细胞质,可增强其致瘤作用,缩短肿瘤出现的时间并降低荷瘤动物的寿命。相反,在类似条件下的细胞壁制剂则产生治疗效果。有人提出一种假设,即这些制剂的作用与其对免疫系统的不同影响有关。

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