Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, 45110 Ioannina, Greece.
Nutrients. 2024 Sep 17;16(18):3133. doi: 10.3390/nu16183133.
Secreted frizzled-related protein 5 (Sfrp5) is an anti-inflammatory adipokine that has been implicated in the pathophysiology of obesity and its metabolic complications. Despite the fact that numerous studies have been carried out in adults, limited data on Sfrp5 exist for youth, especially in relation to overweight and obesity. In our study, we assessed the concentrations of Sfrp5, total oxidative (TOS) and antioxidative (TAS) status, high-sensitivity -reactive protein (hs-CRP), and several cytokines (IL-1α, IL-1β, IL-2, IL-6, IL-8, IL-12, TNF-α) in 120 children and adolescents (mean age ± SE: 11.48 ± 0.25 years; 48 prepubertal, 72 pubertal; 74 males and 46 females) before and 1 year after the implementation of a personalized, structured, lifestyle intervention program of healthy diet, sleep, and physical exercise. Based on the body mass index (BMI), participants were categorized as having morbid obesity ( = 63, 52.5%), obesity ( = 21, 17.5%), overweight ( = 22, 18.33%), or normal BMIs ( = 14, 11.67%), based on the International Obesity Task Force (IOTF) cut-off points. Following the 1-year lifestyle intervention program, a significant improvement in anthropometric measurements (BMI, BMI-z score, diastolic blood pressure, WHR, and WHtR), body-composition parameters, hepatic enzymes, lipid profile, inflammation markers, and the insulin-sensitivity profile (HbA1C, HOMA index) was observed in all subjects. Sfrp5 decreased in subjects with obesity ( < 0.01); however, it increased significantly ( < 0.05) in patients with morbid obesity. Linear regression analysis indicates that TNF-α and systolic blood pressure were the best positive predictors and hs-CRP was the best negative predictor for Sfpr5 concentration at initial assessment and glucose concentration for ΔSfrp5, while TNF-α and TAS were the best positive predictors for Sfpr5 concentration at annual assessment. These results indicate that Sfrp5 is associated with severe obesity and is increased following weight loss in children and adolescents with morbid obesity. It is also related to metabolic homeostasis, as well as inflammation and oxidative status.
分泌卷曲相关蛋白 5（Sfrp5）是一种抗炎脂肪因子，与肥胖及其代谢并发症的病理生理学有关。尽管已经有许多针对成年人的研究，但关于 Sfrp5 的数据在年轻人中有限，尤其是与超重和肥胖有关。在我们的研究中，我们评估了 120 名儿童和青少年（平均年龄±SE：11.48±0.25 岁；48 名青春期前，72 名青春期；74 名男性和 46 名女性）在实施个性化、结构化的生活方式干预计划（健康饮食、睡眠和体育锻炼）前后 Sfrp5、总氧化（TOS）和抗氧化（TAS）状态、高敏 C 反应蛋白（hs-CRP）和几种细胞因子（IL-1α、IL-1β、IL-2、IL-6、IL-8、IL-12、TNF-α）的浓度。根据体重指数（BMI），参与者根据国际肥胖工作组（IOTF）的切点分为病态肥胖（=63，52.5%）、肥胖（=21，17.5%）、超重（=22，18.33%）或正常 BMI（=14，11.67%）。在 1 年的生活方式干预计划后，所有受试者的体重指数（BMI）、BMI-z 评分、舒张压、腰臀比和腰高比、身体成分参数、肝酶、血脂谱、炎症标志物和胰岛素敏感性参数（HbA1C、HOMA 指数）均显著改善。肥胖患者 Sfrp5 降低（<0.01）；然而，病态肥胖患者的 Sfrp5 显著增加（<0.05）。线性回归分析表明，在初始评估时，TNF-α 和收缩压是 Sfpr5 浓度的最佳正预测因子，hs-CRP 是 Sfpr5 浓度的最佳负预测因子，而葡萄糖浓度是 ΔSfrp5 的最佳预测因子，而 TNF-α 和 TAS 是年度评估时 Sfpr5 浓度的最佳正预测因子。这些结果表明，Sfrp5 与严重肥胖有关，在肥胖儿童和青少年减肥后增加。它还与代谢稳态、炎症和氧化状态有关。
