Tan Xinrui, Wang Xiaoli, Chu Haiping, Liu Honghong, Yi Xiaoqing, Xiao Yanfeng
Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Clin Endocrinol (Oxf). 2014 Sep;81(3):363-9. doi: 10.1111/cen.12361. Epub 2013 Dec 12.
Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine, which has been shown as a mediator between obesity and its comorbidities. The aim of this study was to evaluate the associations of SFRP5 with metabolic syndrome (MetS) and the effects of lifestyle interventions on circulating SFRP5 levels in children.
A cross-sectional study was conducted among 111 obese children and 49 lean controls, and a lifestyle intervention was performed in a subgroup of 31 obese children for 6 months. Anthropometric parameters, clinical data and circulating SFRP5 levels were measured at baseline and after lifestyle intervention.
Secreted frizzled-related protein 5 was significantly lower in obese children, especially in those with MetS, and negatively correlated with body mass index (BMI), waist circumference and homeostasis model assessment of insulin resistance. Independent of other well-known risk factors, SFRP5 was a significant predictor of MetS in children. In the longitudinal study, lifestyle intervention led to significant weight loss and higher SFRP5 levels. Furthermore, changes in BMI significantly correlated with the rising magnitude of SFRP5.
Serum SFRP5 is regulated by weight status and seems to be correlated with metabolic disorders in children.
分泌型卷曲相关蛋白5(SFRP5)是一种新型抗炎脂肪因子,已被证明是肥胖及其合并症之间的介质。本研究旨在评估SFRP5与儿童代谢综合征(MetS)的相关性以及生活方式干预对儿童循环SFRP5水平的影响。
对111名肥胖儿童和49名瘦对照儿童进行了横断面研究,并对31名肥胖儿童亚组进行了为期6个月的生活方式干预。在基线和生活方式干预后测量人体测量参数、临床数据和循环SFRP5水平。
肥胖儿童,尤其是患有MetS的儿童,分泌型卷曲相关蛋白5显著降低,且与体重指数(BMI)、腰围和胰岛素抵抗稳态模型评估呈负相关。独立于其他已知危险因素,SFRP5是儿童MetS的重要预测指标。在纵向研究中,生活方式干预导致体重显著减轻和SFRP5水平升高。此外,BMI的变化与SFRP5升高幅度显著相关。
血清SFRP5受体重状态调节,似乎与儿童代谢紊乱相关。