Department of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, Weifang, 261031, China; Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, 261031, China.
Department of Pathophysiology, School of Basic Medical Sciences, Weifang Medical University, Weifang, 261053, China.
Biochem Biophys Res Commun. 2023 Oct 15;677:70-76. doi: 10.1016/j.bbrc.2023.08.008. Epub 2023 Aug 3.
Metabolic diseases pose a significant global health challenge, characterized by an imbalance in metabolism and resulting in various complications. Secreted frizzled-related protein 5 (SFRP5), an adipokine known for its anti-inflammatory properties, has gained attention as a promising therapeutic target for metabolic diseases. SFRP5 acts as a key regulator in the Wnt signaling pathway, exerting its influence on critical cellular functions including proliferation, differentiation, and migration. Its significance extends to the realm of adipose tissue biology, where it plays a central role in regulating inflammation, insulin resistance, adipogenesis, lipid metabolism, glucose homeostasis, and energy balance. By inhibiting Wnt signaling, SFRP5 facilitates adipocyte growth, promotes lipid accumulation, and contributes to a decrease in oxidative metabolism. Lifestyle interventions and pharmacological treatments have shown promise in increasing SFRP5 levels and protecting against metabolic abnormalities. SFRP5 is a pivotal player in metabolic diseases and presents itself as a promising therapeutic target. An overview of SFRP5 and its involvement in metabolic disorders and metabolism is provided in this comprehensive review. By elucidating these aspects, valuable insights can be gained to foster the development of effective strategies in combating metabolic diseases.
代谢性疾病构成了重大的全球健康挑战，其特征是代谢失衡，并导致各种并发症。分泌卷曲相关蛋白 5（SFRP5）是一种具有抗炎特性的脂肪因子，作为代谢性疾病有前途的治疗靶点引起了关注。SFRP5 作为 Wnt 信号通路的关键调节剂，对包括增殖、分化和迁移在内的关键细胞功能发挥作用。其意义延伸到脂肪组织生物学领域，在该领域，它在调节炎症、胰岛素抵抗、脂肪生成、脂质代谢、葡萄糖稳态和能量平衡方面发挥着核心作用。通过抑制 Wnt 信号，SFRP5 促进脂肪细胞生长、促进脂质积累，并有助于降低氧化代谢。生活方式干预和药物治疗已显示出增加 SFRP5 水平和预防代谢异常的潜力。SFRP5 是代谢性疾病的关键参与者，是一个很有前途的治疗靶点。本综述概述了 SFRP5 及其在代谢紊乱和代谢中的作用。阐明这些方面可以获得有价值的见解，以促进对抗代谢性疾病的有效策略的发展。
