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Cell Rep Med. 2024 Jul 16;5(7):101642. doi: 10.1016/j.xcrm.2024.101642. Epub 2024 Jul 8.
2
Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection.在 SARS-CoV-2 感染后,基于组织的 T 细胞激活和病毒 RNA 可持续长达 2 年。
Sci Transl Med. 2024 Jul 3;16(754):eadk3295. doi: 10.1126/scitranslmed.adk3295.
3
Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection: The STOP-PASC Randomized Clinical Trial.尼马瑞韦/利托那韦片和成年人 SARS-CoV-2 感染后后遗症症状:STOP-PASC 随机临床试验。
JAMA Intern Med. 2024 Sep 1;184(9):1024-1034. doi: 10.1001/jamainternmed.2024.2007.
4
Evidence Mounts That About 7% of US Adults Have Had Long COVID.越来越多的证据表明,美国约7%的成年人患有长期新冠后遗症。
JAMA. 2024 Jul 2;332(1):5-6. doi: 10.1001/jama.2024.11370.
5
The Potential Role of Viral Persistence in the Post-Acute Sequelae of SARS-CoV-2 Infection (PASC).病毒持续存在在新冠病毒感染后急性后遗症(PASC)中的潜在作用
Pathogens. 2024 May 8;13(5):388. doi: 10.3390/pathogens13050388.
6
Persistent SARS-CoV-2 infection: significance and implications.持续的 SARS-CoV-2 感染:意义和影响。
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Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2.长新冠表现为 T 细胞失调、炎症和对 SARS-CoV-2 的不协调适应性免疫反应。
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与持续存在的病毒抗原和炎症相关的长期 SARS-CoV-2 发现与流感病毒和呼吸道合胞病毒的报告相似。

Long-Term SARS-CoV-2 Findings Related to Persisting Viral Antigen and Inflammation Resemble Those Reported for Influenza Virus and Respiratory Syncytial Virus.

机构信息

Division of Infectious Diseases and Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.

Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.

出版信息

Viruses. 2024 Aug 24;16(9):1353. doi: 10.3390/v16091353.

DOI:10.3390/v16091353
PMID:39339830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11436236/
Abstract

Recent studies have documented prolonged expression of viral antigens and RNA and associated inflammation after infection with SARS-CoV-2 in a substantial proportion of infected patients. The persisting SARS-CoV-2 effects and findings, with inflammation associated with continued detection of viral antigens, especially resemble those previously reported for influenza virus, as well as respiratory syncytial virus (RSV). The reports indicate the need for improved insight into the mechanisms whereby post-SARS-CoV-2 infection-related illness is apparently more common and perhaps even more persistent after infection than observed for other respiratory viruses.

摘要

最近的研究记录表明,在相当一部分感染 SARS-CoV-2 的患者中,病毒抗原和 RNA 的表达以及相关炎症持续时间延长。持续存在的 SARS-CoV-2 效应和发现,以及与持续检测病毒抗原相关的炎症,特别类似于以前报道的流感病毒和呼吸道合胞病毒 (RSV)。这些报告表明,需要更好地了解机制,即与 SARS-CoV-2 感染相关的疾病在感染后似乎比其他呼吸道病毒更常见,甚至更持久。