Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Department of Ophthalmology, Ospedali Privati Forlì "Villa Igea", 47122 Forlì, Italy.
Viruses. 2024 Aug 31;16(9):1403. doi: 10.3390/v16091403.
Herpes simplex virus (HSV) is one of the most common etiologic agents of corneal disease and a significant cause of corneal blindness worldwide. Although most cases can be successfully managed with medical therapy, HSV keratitis associated with visually significant stromal scarring often requires corneal transplantation for visual rehabilitation. While penetrating keratoplasty (PK) represented the traditional keratoplasty technique, the past few decades have seen a shift towards lamellar keratoplasty procedures, including deep anterior lamellar keratoplasty and mushroom keratoplasty. This paper describes the current surgical techniques and perioperative antiviral prophylaxis regimen for herpetic keratitis and reviews their postoperative clinical outcomes.
单纯疱疹病毒(HSV)是引起角膜疾病的最常见病因之一,也是全球范围内导致角膜盲的主要原因。虽然大多数病例可以通过药物治疗成功控制,但与明显的基质混浊相关的 HSV 角膜炎常需要角膜移植以恢复视力。虽然穿透性角膜移植术(PK)是传统的角膜移植技术,但在过去几十年中,人们越来越倾向于采用板层角膜移植术,包括深层前板层角膜移植术和蘑菇状角膜移植术。本文描述了治疗疱疹性角膜炎的当前手术技术和围手术期抗病毒预防方案,并回顾了它们的术后临床结果。