Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
Viruses. 2024 Sep 1;16(9):1404. doi: 10.3390/v16091404.
Vaccination has led to significant dismantling of infectious diseases worldwide. Since the dawn of the SARS-CoV-2 pandemic, there has been increased popularity in the usage and study of the mRNA vaccine platform. Here, we highlight fundamental knowledge on mRNA vaccine pharmacology, followed by the immunity conferred by innate sensing and adaptive responses resulting from exposure to the mRNA vaccine construct and encapsulation materials. A better understanding of these immune mechanisms will shed light on further improvements in mRNA vaccine design, aiming to improve efficiency and optimize immune responses upon inoculation.
疫苗接种已在全球范围内显著消除了传染病。自 SARS-CoV-2 大流行开始以来，mRNA 疫苗平台的使用和研究日益普及。在这里，我们重点介绍 mRNA 疫苗药理学的基础知识，然后介绍先天感应和适应性反应所赋予的免疫力，这些反应是由于暴露于 mRNA 疫苗构建体和封装材料引起的。更好地了解这些免疫机制将有助于进一步改进 mRNA 疫苗设计，旨在提高接种效率和优化免疫反应。
