mRNA 疫苗有助于先天和适应性免疫，增强体内免疫反应。
mRNA vaccines contribute to innate and adaptive immunity to enhance immune response in vivo.
机构信息
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China; Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen, 361005, China; Institute of Functional Nano and Soft Materials, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, 215123, China.
出版信息
Biomaterials. 2024 Oct;310:122628. doi: 10.1016/j.biomaterials.2024.122628. Epub 2024 May 28.
Messenger RNA (mRNA) therapeutics have been widely employed as strategies for the treatment and prevention of diseases. Amid the global outbreak of COVID-19, mRNA vaccines have witnessed rapid development. Generally, in the case of mRNA vaccines, the initiation of the innate immune system serves as a prerequisite for triggering subsequent adaptive immune responses. Critical cells, cytokines, and chemokines within the innate immune system play crucial and beneficial roles in coordinating tailored immune reactions towards mRNA vaccines. Furthermore, immunostimulators and delivery systems play a significant role in augmenting the immune potency of mRNA vaccines. In this comprehensive review, we systematically delineate the latest advancements in mRNA vaccine research, present an in-depth exploration of strategies aimed at amplifying the immune effectiveness of mRNA vaccines, and offer some perspectives and recommendations regarding the future advancements in mRNA vaccine development.
信使 RNA（mRNA）疗法已被广泛用作治疗和预防疾病的策略。在 COVID-19 全球大流行期间，mRNA 疫苗得到了快速发展。通常情况下，对于 mRNA 疫苗而言，先天免疫系统的启动是触发随后的适应性免疫反应的前提。先天免疫系统中的关键细胞、细胞因子和趋化因子在协调针对 mRNA 疫苗的定制免疫反应方面发挥着关键和有益的作用。此外，免疫佐剂和递送系统在增强 mRNA 疫苗的免疫效力方面发挥着重要作用。在这篇全面的综述中，我们系统地描述了 mRNA 疫苗研究的最新进展，深入探讨了增强 mRNA 疫苗免疫效果的策略，并对 mRNA 疫苗开发的未来进展提出了一些观点和建议。
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