Siddique Abubakar, Wang Zining, Zhou Haiyang, Huang Linlin, Jia Chenghao, Wang Baikui, Ed-Dra Abdelaziz, Teng Lin, Li Yan, Yue Min
Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Sciences, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Vaccines (Basel). 2024 Sep 18;12(9):1067. doi: 10.3390/vaccines12091067.
is a significant zoonotic foodborne pathogen, and the global spread of multidrug-resistant (MDR) strains poses substantial challenges, necessitating alternatives to antibiotics. Among these alternatives, vaccines protect the community against infectious diseases effectively. This review aims to summarize the efficacy of developed vaccines evaluated in various animal hosts and highlight key transitions for future vaccine studies. A total of 3221 studies retrieved from Web of Science, Google Scholar, and PubMed/Medline databases between 1970 and 2023 were evaluated. One hundred twenty-seven qualified studies discussed the vaccine efficacy against typhoidal and nontyphoidal serovars, including live-attenuated vaccines, killed inactivated vaccines, outer membrane vesicles, outer membrane complexes, conjugate vaccines, subunit vaccines, and the reverse vaccinology approach in different animal hosts. The most efficacious vaccine antigen candidate found was recombinant heat shock protein (rHsp60) with an incomplete Freund's adjuvant evaluated in a murine model. Overall, bacterial ghost vaccine candidates demonstrated the highest efficacy at 91.25% (95% CI = 83.69-96.67), followed by the reverse vaccinology approach at 83.46% (95% CI = 68.21-94.1) across animal hosts. More than 70% of vaccine studies showed significant production of immune responses, including humoral and cellular, against infection. Collectively, the use of innovative methods rather than traditional approaches for the development of new effective vaccines is crucial and warrants in-depth studies.
是一种重要的人畜共患食源性病原体，多重耐药（MDR）菌株的全球传播带来了巨大挑战，因此需要抗生素的替代物。在这些替代物中，疫苗能有效保护社区免受传染病侵害。本综述旨在总结在各种动物宿主中评估的已开发疫苗的疗效，并突出未来疫苗研究的关键转变。对1970年至2023年间从科学网、谷歌学术和PubMed/Medline数据库中检索到的3221项研究进行了评估。127项合格研究讨论了针对伤寒和非伤寒血清型的疫苗疗效，包括减毒活疫苗、灭活疫苗、外膜囊泡、外膜复合物、结合疫苗、亚单位疫苗以及在不同动物宿主中的反向疫苗学方法。发现最有效的疫苗抗原候选物是在小鼠模型中用不完全弗氏佐剂评估的重组热休克蛋白（rHsp60）。总体而言，细菌幽灵疫苗候选物在动物宿主中的疗效最高，为91.25%（95%CI = 83.69 - 96.67），其次是反向疫苗学方法，为83.46%（95%CI = 68.21 - 94.1）。超过70%的疫苗研究表明，针对感染产生了显著的免疫反应，包括体液免疫和细胞免疫。总的来说，使用创新方法而非传统方法来开发新的有效疫苗至关重要，值得深入研究。
