Ke Yefang, Teng Lin, Zhu Zhe, Lu Wenbo, Liu Wenyuan, Zhou Haiyang, Yu Qi, Ye Lina, Zhu Pan, Zhao Guoping, Yue Min
Department of Clinical Laboratory Ningbo Women and Children's Hospital Ningbo China.
Department of Veterinary Medicine Zhejiang University College of Animal Sciences Hangzhou China.
mLife. 2024 Mar 29;3(1):156-160. doi: 10.1002/mlf2.12117. eCollection 2024 Mar.
Invasive nontyphoidal (iNTS) causes significant concern with ~15% morbidity, affecting populations mainly in African countries. However, iNTS infections among the Chinese pediatric population remain largely unknown. Here, we conducted a genomic investigation to study pediatric iNTS infections in a Chinese hospital. iNTS isolates accounted for 15.2% (18/119) of all nontyphoidal (NTS) strains. Compared to non-iNTS isolates, iNTS isolates harbored a lower prevalence of antimicrobial-resistant genes of fluoroquinolones and β-lactams, as well as disinfectant determinants and plasmids, but carried a significantly higher prevalence of , , and genes. Importantly, we detected an emerging serovar Goldcoast as the predominant iNTS serovar locally. By integrating 320 global Goldcoast genomes based on the One Health samplings, we conducted nationwide phylogenomic tracking and detected repeated human-to-human transmission events among iNTS cases caused by an underestimated serovar Goldcoast. Together, our exploratory genomic approach highlights a new trend in pediatric iNTS infections.
侵袭性非伤寒沙门氏菌（iNTS）引起了极大关注，其发病率约为15%，主要影响非洲国家的人群。然而，中国儿童群体中的iNTS感染情况在很大程度上仍不为人知。在此，我们进行了一项基因组调查，以研究一家中国医院中的儿童iNTS感染情况。iNTS分离株占所有非伤寒沙门氏菌（NTS）菌株的15.2%（18/119）。与非iNTS分离株相比，iNTS分离株中氟喹诺酮类和β-内酰胺类抗菌耐药基因、消毒剂决定簇和质粒的携带率较低，但携带的、和基因的流行率显著更高。重要的是，我们检测到一种新兴的血清型黄金海岸作为当地主要的iNTS血清型。通过基于“同一健康”采样整合320个全球黄金海岸基因组，我们进行了全国范围的系统发育基因组追踪，并在由一种未被充分认识的血清型黄金海岸引起的iNTS病例中检测到多次人传人传播事件。总之，我们的探索性基因组方法突出了儿童iNTS感染的一个新趋势。
