Department of Thyroid and Breast Surgery, Wuhan No. 1 Hospital, Wuhan, China.
Department of Thyroid and Breast Surgery, Tongji Hospital affiliated with Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
J Int Med Res. 2024 Sep;52(9):3000605241281322. doi: 10.1177/03000605241281322.
Previous research has shown that the role of neurotrophic receptor tyrosine kinase 2 (NTRK2) in breast cancer (BRCA) remains ambiguous. To help elucidate this, we conducted a retrospective study to investigate the relationship between NTRK2 protein expression and BRCA.
The prognostic significance of NTRK2 protein expression patterns was assessed by performing immunohistochemistry assays on 131 BRCA tissues and 56 adjacent normal tissues in a retrospective study. Furthermore, the sensitivity to chemotherapeutic drugs was quantified by "pRRophetic" and the sensitivity to immunotherapy was estimated using The Cancer Immunome Atlas website.
NTRK2 protein was expressed at significantly higher levels in BRCA samples compared with normal tissues. The data indicated that NTRK2 expression is an independent risk factor for BRCA patient prognosis. Additionally, the high NTRK2 group exhibited increased sensitivity to certain chemotherapy drugs and achieved higher scores for immune checkpoint blockade therapy compared with the low NTRK2 group.
Our study demonstrated that higher NTRK2 protein expression is related to a less favorable prognosis in BRCA patients, as well as to enhanced sensitivity to specific chemotherapy and immunotherapy drugs.
先前的研究表明，神经营养受体酪氨酸激酶 2（NTRK2）在乳腺癌（BRCA）中的作用仍存在争议。为了帮助阐明这一点，我们进行了一项回顾性研究，以调查 NTRK2 蛋白表达与 BRCA 之间的关系。
通过对 131 例 BRCA 组织和 56 例相邻正常组织进行免疫组织化学检测，评估 NTRK2 蛋白表达模式的预后意义。此外，通过“pRRophetic”量化对化疗药物的敏感性，使用 The Cancer Immunome Atlas 网站估计对免疫治疗的敏感性。
与正常组织相比，BRCA 样本中 NTRK2 蛋白表达水平显著升高。数据表明，NTRK2 表达是 BRCA 患者预后的独立危险因素。此外，高 NTRK2 组对某些化疗药物的敏感性增加，并且与低 NTRK2 组相比，免疫检查点阻断治疗的评分更高。
我们的研究表明，较高的 NTRK2 蛋白表达与 BRCA 患者预后不良有关，并且对特定的化疗和免疫治疗药物的敏感性增强。
