5th Medical Department, University Hospital Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany.
IQVIA Epidemiology, IQVIA, Frankfurt/Main, Germany.
Ther Adv Cardiovasc Dis. 2024 Jan-Dec;18:17539447241277402. doi: 10.1177/17539447241277402.
This study quantified the 'distance to LDL-C goal' in patients at very high cardiovascular risk with uncontrolled hyperlipidaemia. 'Distance to LDL-C goal' was defined as the percentage by which low-density lipoprotein cholesterol (LDL-C) levels needed to be reduced to achieve the LDL-C goals specified in the 2016 or 2019 European Society of Cardiology/European Atherosclerosis Society guidelines.
This retrospective analysis using data from the IQVIA Disease Analyzer database included patients who were predominantly treated by a primary care physician, diabetologist or cardiologist between 2014 and 2018, with a diagnosis of hyperlipidaemia and an initial LDL-C measurement (index event) and one or more cardiovascular risk factors. The primary outcome was to assess the proportion of patients with uncontrolled hyperlipidaemia and to classify the 'distance to LDL-C goal' in these patients.
Data from 32,963 patients were analysed ( = 27,159, = 3873 and = 1931 patients in the primary care physician, diabetology and cardiology cohorts, respectively). Most patients had uncontrolled LDL-C levels (⩾70 mg/dL; ⩾1.8 mmol/L) at index (91.0%, 86.4% and 94.0% of patients in the primary care physician, diabetology and cardiology cohorts, respectively). Analysis of the 'distance to LDL-C goal' indicated that approximately one-third of patients in each cohort required an LDL-C level reduction of up to 50% relative to index to achieve their LDL-C goal (35.8%, 43.7% and 28.4% of patients in the primary care physician, diabetology and cardiology cohorts, respectively). LDL-C control was not achieved at 36 months post-index in most patients with uncontrolled LDL-C levels (86.8%, 81.7% and 90.2% of patients in the primary care physician, diabetology and cardiology cohorts, respectively).
LDL-C levels were uncontrolled in most patients with hyperlipidaemia. Analysis of the 'distance to LDL-C goal' showed that most patients required a substantial LDL-C level reduction to achieve their LDL-C goal.
本研究量化了伴有未控制高脂血症的极高心血管风险患者的“距 LDL-C 目标的距离”。“距 LDL-C 目标的距离”定义为需要降低 LDL-C 水平的百分比，以达到 2016 年或 2019 年欧洲心脏病学会/欧洲动脉粥样硬化学会指南规定的 LDL-C 目标。
本回顾性分析使用 IQVIA 疾病分析数据库中的数据，纳入了 2014 年至 2018 年间主要由初级保健医生、糖尿病专家或心脏病专家治疗的、伴有高脂血症初诊 LDL-C 测量（起始事件）和一个或多个心血管危险因素的患者。主要结局是评估未控制高脂血症患者的比例，并对这些患者的“距 LDL-C 目标的距离”进行分类。
分析了 32963 例患者的数据（初级保健医生队列、糖尿病学队列和心脏病学队列分别有 27159 例、3873 例和 1931 例）。大多数患者的 LDL-C 水平在起始时未得到控制（≥70mg/dL；初级保健医生、糖尿病学和心脏病学队列中分别有 86.4%、94.0%和 91.0%的患者）。“距 LDL-C 目标的距离”分析表明，每个队列中约有三分之一的患者需要将 LDL-C 水平降低 50%相对起始值，以达到其 LDL-C 目标（初级保健医生、糖尿病学和心脏病学队列中分别有 35.8%、43.7%和 28.4%的患者）。大多数 LDL-C 水平未得到控制的患者在起始后 36 个月时未达到 LDL-C 控制（初级保健医生、糖尿病学和心脏病学队列中分别有 86.8%、81.7%和 90.2%的患者）。
大多数高脂血症患者的 LDL-C 水平未得到控制。“距 LDL-C 目标的距离”分析表明，大多数患者需要显著降低 LDL-C 水平才能达到其 LDL-C 目标。
