Reduced aggregation capacity of washed platelets and dysfibrinogenaemia in rats given butylated hydroxytoluene.

Calcium-dependent aggregation of washed platelets and the fibrin monomer polymerization (FMP) ratio were determined in rats fed 1.20% butylated hydroxytoluene (BHT) for 7 days. Thrombin-induced aggregation was significantly reduced in rats given BHT, but calcium ionophore A23187-induced aggregation was not. The FMP ratio was significantly increased by BHT administration. These results provide additional evidence of defective platelet function and coagulation-factor abnormality (dysfibrinogenaemia) in rats fed BHT.