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[肝胰胆外科手术中的吻合口漏]

[Anastomotic leakage in hepato-pancreato-biliary surgery].

作者信息

Birgin Emrullah, Heil Jan, Walter Benjamin, Wagner Martin, Müssle Benjamin, Kornmann Marko, Seufferlein Thomas, Rahbari Nuh N

机构信息

Klinik für Allgemein- und Viszeralchirurgie, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland.

Klinik für Innere Medizin 1, Universitätsklinikum Ulm, Ulm, Deutschland.

出版信息

Chirurgie (Heidelb). 2024 Nov;95(11):887-894. doi: 10.1007/s00104-024-02176-w. Epub 2024 Sep 28.

DOI:10.1007/s00104-024-02176-w
PMID:39340543
Abstract

Severe complications following hepato-pancreato-biliary surgery are frequently due to leakage of anastomoses. Local intraoperative and systematic measures can reduce the incidence of leaks and leak-related sequelae. The early identification of leak-related sequelae, such as hemorrhage is pivotal to reduce the mortality risk. Therefore, perioperative risk stratification incorporating surgical and patient risk factors is crucial. The management of anastomotic leaks is complex and an interdisciplinary treatment is therefore recommended. The treatment depends on the institutional expertise, localization, characteristic features of the anastomosis and the onset of insufficiency. This article describes the different concepts of the diagnostics, prevention, consequences and management of anastomotic leakage in hepato-pancreato-biliary surgery in more detail.

摘要

肝胰胆手术后的严重并发症常常归因于吻合口漏。术中局部措施和全身措施可降低吻合口漏及其相关后遗症的发生率。早期识别与漏相关的后遗症,如出血,对于降低死亡风险至关重要。因此,纳入手术和患者风险因素的围手术期风险分层至关重要。吻合口漏的处理较为复杂,因此建议采用多学科治疗。治疗方法取决于机构的专业水平、漏的部位、吻合口的特征以及功能不全的发生时间。本文将更详细地描述肝胰胆手术中吻合口漏的诊断、预防、后果及处理的不同概念。

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1
[Anastomotic leakage in hepato-pancreato-biliary surgery].[肝胰胆外科手术中的吻合口漏]
Chirurgie (Heidelb). 2024 Nov;95(11):887-894. doi: 10.1007/s00104-024-02176-w. Epub 2024 Sep 28.
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本文引用的文献

1
Somatostatin Versus Octreotide for Prevention of Postoperative Pancreatic Fistula: The PREFIPS Randomized Clinical Trial: A FRENCH 007-ACHBT Study.生长抑素与奥曲肽预防术后胰瘘的比较:PREFIPS 随机临床试验:一项法国 007-ACHBT 研究。
Ann Surg. 2024 Aug 1;280(2):179-187. doi: 10.1097/SLA.0000000000006313. Epub 2024 Apr 25.
2
Prophylactic abdominal drainage after distal pancreatectomy (PANDORINA): an international, multicentre, open-label, randomised controlled, non-inferiority trial.预防性腹部引流在胰体尾切除术后(PANDORINA):一项国际性、多中心、开放性标签、随机对照、非劣效性临床试验。
Lancet Gastroenterol Hepatol. 2024 May;9(5):438-447. doi: 10.1016/S2468-1253(24)00037-2. Epub 2024 Mar 16.
3
Development and Validation of a Model for Postpancreatectomy Hemorrhage Risk.
开发和验证一种用于胰腺切除术后出血风险的模型。
JAMA Netw Open. 2023 Dec 1;6(12):e2346113. doi: 10.1001/jamanetworkopen.2023.46113.
4
Perianastomotic Irrigation With Passive Drainage Dramatically Decreases POPF Rate After High-risk Pancreaticoduodenectomy.高风险胰十二指肠切除术后,吻合口周围灌洗联合被动引流可显著降低胰瘘发生率。
Ann Surg Open. 2022 Apr 15;3(2):e154. doi: 10.1097/AS9.0000000000000154. eCollection 2022 Jun.
5
Abdominal drainage is contraindicated after uncomplicated hepatectomy: Results of a meta-analysis of randomized controlled trials.单纯肝切除术后禁忌行腹腔引流:一项随机对照试验的Meta分析结果
Surgery. 2023 Feb;173(2):401-411. doi: 10.1016/j.surg.2022.10.023. Epub 2022 Nov 22.
6
Pure biliary leak vs. pancreatic fistula associated: non-identical twins following pancreatoduodenectomy.单纯胆漏与胰瘘相关:胰十二指肠切除术后的同卵双胞胎。
HPB (Oxford). 2022 Sep;24(9):1474-1481. doi: 10.1016/j.hpb.2022.03.001. Epub 2022 Mar 16.
7
Preoperative risk stratification of postoperative pancreatic fistula: A risk-tree predictive model for pancreatoduodenectomy.术前术后胰瘘风险分层:胰十二指肠切除术的风险树预测模型。
Surgery. 2021 Dec;170(6):1596-1601. doi: 10.1016/j.surg.2021.06.046. Epub 2021 Jul 24.
8
Prophylactic Intra-Peritoneal Drainage After Pancreatic Resection: An Updated Meta-Analysis.胰腺切除术后预防性腹腔引流:一项更新的荟萃分析。
Front Oncol. 2021 May 20;11:658829. doi: 10.3389/fonc.2021.658829. eCollection 2021.
9
Cholangitis following biliary-enteric anastomosis: A systematic review and meta-analysis.胆肠吻合术后胆管炎:系统评价和荟萃分析。
Pancreatology. 2020 Jun;20(4):736-745. doi: 10.1016/j.pan.2020.04.017. Epub 2020 Apr 30.
10
Left- versus right-sided hepatectomy with hilar en-bloc resection in perihilar cholangiocarcinoma.左右半肝切除术联合肝门整块切除术治疗肝门周围型胆管细胞癌。
HPB (Oxford). 2020 Mar;22(3):437-444. doi: 10.1016/j.hpb.2019.07.003. Epub 2019 Aug 2.