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卵巢组织冻存与移植——一种自然延缓绝经的方法。

Ovarian tissue cryopreservation and transplantation as a natural means to delay menopause.

机构信息

Department of Obstetrics and Gynecology, Aksaray University Training and Research Hospital, Aksaray, Turkey.

Division of Epidemiology, Department of Public Health, Hacettepe University Faculty of Medicine, Ankara, Turkey.

出版信息

Arch Gynecol Obstet. 2024 Nov;310(5):2305-2313. doi: 10.1007/s00404-024-07752-3. Epub 2024 Sep 28.

Abstract

Ovarian tissue cryopreservation and transplantation (OTCT) offers hope for preserving fertility and endocrine functions in patients undergoing gonadotoxic treatments. Advancements in techniques for the procedure have transformed OTCT from an experimental procedure into a viable option. There is a growing interest in utilizing OTCT to delay menopause and alleviate associated health issues. Menopausal transition affects women globally, leading to symptoms and long- term health risks. OTCT has the potential to restore endocrine functions, reducing menopause-related symptoms while mitigating health consequences such as osteoporosis and cardiovascular diseases. Although the use of OTCT for delaying menopause is not clinically proven, the discussion around shows potential for future utilization. In essence, the remarkable advancements in OTCT have bestowed upon us the ability to safeguard fertility and sustain the delicate endocrine functions of the ovaries. However, it is the tantalizing prospect of utilizing this technique to postpone menopause and alleviate its associated symptoms that truly captivates the imagination. Further research is imperative to substantiate the clinical efficacy of OTCT; nonetheless, its potential in menopausal therapy is both promising and warrants comprehensive exploration. This review highlights advancements and the feasibility of OTCT to postpone menopause as an alternative approach to currently used conventional menopause therapy methods.

摘要

卵巢组织冷冻保存和移植(OTCT)为接受性腺毒性治疗的患者保留生育力和内分泌功能提供了希望。该手术技术的进步已经将 OTCT 从实验性手术转变为可行的选择。利用 OTCT 来延迟绝经并缓解相关健康问题的兴趣日益增加。绝经过渡影响着全球的女性,导致出现症状和长期健康风险。OTCT 有可能恢复内分泌功能,减轻与绝经相关的症状,同时减轻骨质疏松症和心血管疾病等健康后果。尽管 OTCT 用于延迟绝经尚未在临床上得到证实,但围绕该问题的讨论表明了未来的潜在应用。从本质上讲,OTCT 的显著进步使我们能够保护生育力并维持卵巢的微妙内分泌功能。然而,利用这项技术来推迟绝经并缓解相关症状的诱人前景确实令人着迷。进一步的研究对于证实 OTCT 的临床疗效至关重要;尽管如此,其在绝经治疗中的潜力具有广阔的前景,值得全面探索。本综述强调了 OTCT 在延迟绝经方面的进展和可行性,将其作为目前使用的传统绝经治疗方法的替代方法。

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