Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA; Innovation Institute for Fertility Preservation, New York, NY, USA.
Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA; Department of Women's and Children's Health, University of Padua, Padua, Italy.
Trends Mol Med. 2021 Aug;27(8):753-761. doi: 10.1016/j.molmed.2021.01.005. Epub 2021 Feb 4.
Ovarian tissue cryopreservation and autotransplantation can restore ovarian endocrine function and fertility and recently were changed from experimental to fertility preservation procedures for medical indications by the American Society of Reproductive Medicine. Such advances have resulted in discussions around the utility of ovarian cryopreservation in healthy women to preserve fertility and delay menopause or as a hormone replacement approach. Such 'elective' use of ovarian tissue cryopreservation requires a risk-benefit assessment. Here, we review evidence for and against the utility of ovarian tissue harvesting in healthy women, scrutinize recent and needed advances to enhance the feasibility of such an approach, and provide practice and future research guidelines.
卵巢组织冷冻保存和自体移植可以恢复卵巢内分泌功能和生育能力，最近已被美国生殖医学学会从实验性生育保存程序改为医疗适应证。这些进展引发了关于在健康女性中使用卵巢冷冻保存来保存生育能力和延迟绝经或作为激素替代方法的效用的讨论。这种“选择性”使用卵巢组织冷冻保存需要进行风险效益评估。在这里，我们回顾了在健康女性中进行卵巢组织采集的益处和风险的证据，仔细审查了最近和需要的进展，以提高这种方法的可行性，并提供实践和未来研究的指导方针。
