Laboratory of Phytopharmacology and Special Nutrition, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Bull Exp Biol Med. 2024 Sep;177(5):648-652. doi: 10.1007/s10517-024-06242-5. Epub 2024 Sep 28.
It was found that the diterpene alkaloid songorine administered per os to mice at a dose of 25 μg/kg provides a pronounced anxiolytic effect during elevated plus maze testing comparable to the effect of the benzodiazepine anxiolytic phenazepam. Recording of ultrasonic vocalizations of animals revealed an increase in the number of short high-frequency (50 kHz) signals under the action of songorine and the reference drug, which confirms their anti-anxiety properties.
研究发现，当给小鼠口服 25μg/kg 的二萜生物碱歌柔豚碱时，它在高架十字迷宫测试中提供了明显的抗焦虑作用，可与苯二氮䓬类抗焦虑药苯甲二氮䓬相当。对动物的超声波发声记录显示，在歌柔豚碱和参考药物的作用下，短高频（50kHz）信号的数量增加，这证实了它们的抗焦虑特性。
