超小剂量苯氮卓对多种焦虑模型大鼠脑生物电活动及行为的影响
Effects of phenazepam in ultralow doses on bioelectric activity of the brain and behavior of rats in various models of anxiety.
作者信息
Voronina T A, Molodavkin G M, Chernyavskaya L I, Seredenin S B, Burlakova E B
机构信息
Laboratory of Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences.
出版信息
Bull Exp Biol Med. 2003 Jan;135 Suppl 7:14-6. doi: 10.1023/a:1024793621810.
Phenazepam in ultralow doses produced an anxiolytic effect on male outbred albino rats in the conflict situation and elevated plus-maze models and inhibited theta-activity in EEG, which is typical of tranquilizers. As differentiated from standard doses, phenazepam in this concentration did not affect other frequency bands. Our results suggest that phenazepam in ultralow doses acts as the anxioselective tranquilizer.
超低剂量的芬那西泮在冲突情境和高架十字迷宫模型中对雄性远交白化大鼠产生抗焦虑作用，并抑制脑电图中的θ波活动，这是镇静剂的典型特征。与标准剂量不同，该浓度的芬那西泮不影响其他频段。我们的结果表明，超低剂量的芬那西泮具有抗焦虑选择性镇静作用。
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