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一种利用硅基生物活性材料加速正常愈合来抑制瘢痕形成的新策略。

A New Strategy to Inhibit Scar Formation by Accelerating Normal Healing Using Silicate Bioactive Materials.

机构信息

Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, P. R. China.

Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325000, P. R. China.

出版信息

Adv Sci (Weinh). 2024 Nov;11(43):e2407718. doi: 10.1002/advs.202407718. Epub 2024 Sep 28.

DOI:10.1002/advs.202407718
PMID:39340818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11578354/
Abstract

Inspired by the scar-free wound healing in infants, an anti-scar strategy is proposed by accelerating wound healing using silicate bioactive materials. Bioglass/alginate composite hydrogels are applied, which significantly inhibit scar formation in rabbit ear scar models. The underlining mechanisms include stimulation of Integrin Subunit Alpha 2 expression in dermal fibroblasts to accelerate wound healing, and induction of apoptosis of hypertrophic scar fibroblasts by directly stimulating the N-Acylsphingosine Amidohydrolase 2 expression in hypertrophic scar fibroblasts, and indirectly upregulating the secretion of Cathepsin K in dermal fibroblasts. Considering specific functions of the bioactive silicate materials, two scar treatment regimes are tested. For severe scars, a regenerative intervention is applied by surgical removal of the scar followed by the treatment with bioactive hydrogels to reduce the formation of scars by activating dermal fibroblasts. For mild scars, the bioactive dressing is applied on the formed scar and reduces scar by inducing scar fibroblasts apoptosis.

摘要

受婴儿无痕伤口愈合的启发，提出了一种通过使用硅酸盐生物活性材料加速伤口愈合来预防疤痕的策略。应用生物玻璃/藻酸盐复合水凝胶，可显著抑制兔耳瘢痕模型中的瘢痕形成。其潜在机制包括刺激真皮成纤维细胞中整合素亚基α 2 的表达，以加速伤口愈合，以及通过直接刺激增生性瘢痕成纤维细胞中的 N-酰基鞘氨醇酰胺水解酶 2 的表达，并间接上调真皮成纤维细胞中组织蛋白酶 K 的分泌，从而诱导增生性瘢痕成纤维细胞凋亡。考虑到生物活性硅酸盐材料的特定功能，测试了两种瘢痕治疗方案。对于严重的瘢痕，通过手术切除瘢痕，然后用生物活性水凝胶进行治疗，以通过激活真皮成纤维细胞来减少瘢痕形成，进行再生干预。对于轻度瘢痕，将生物活性敷料应用于形成的瘢痕上，通过诱导瘢痕成纤维细胞凋亡来减轻瘢痕。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51de/11578354/46715e7dea62/ADVS-11-2407718-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51de/11578354/19570bad15f8/ADVS-11-2407718-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51de/11578354/e90f039d3ed3/ADVS-11-2407718-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51de/11578354/ff981b390dcf/ADVS-11-2407718-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51de/11578354/46715e7dea62/ADVS-11-2407718-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51de/11578354/19570bad15f8/ADVS-11-2407718-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51de/11578354/25ba49b587f1/ADVS-11-2407718-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51de/11578354/222d4f660582/ADVS-11-2407718-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51de/11578354/1a0c2956a703/ADVS-11-2407718-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51de/11578354/e90f039d3ed3/ADVS-11-2407718-g009.jpg
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