Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, China; University of Chinese Academy of Sciences, Beijing, China.
College of Animal Science and Technology, Hunan Agriculture University, Changsha, China.
Adv Nutr. 2024 Nov;15(11):100307. doi: 10.1016/j.advnut.2024.100307. Epub 2024 Sep 26.
Although research on the role of iron in host immunity has a history spanning decades, it is only relatively recently that attention has been directed toward the biological effects of iron on the intestinal mucus layer, prompted by an evolving understanding of the role of this material in immune defense. The mucus layer, secreted by intestinal goblet cells, covers the intestinal epithelium, and given its unique location, interactions between the host and gut microbiota, as well as among constituent microbiota, occur frequently within the mucus layer. Iron, as an essential nutrient for the vast majority of life forms, regulates immune responses from both the host and microbial perspectives. In this review, we summarize the iron metabolism of both the host and gut microbiota and describe how iron contributes to intestinal mucosal homeostasis via the intestinal mucus layer with respect to both host and constituent gut microbiota. The findings described herein offer a new perspective on iron-mediated intestinal mucosal barrier function.
尽管铁在宿主免疫中的作用的研究已经有几十年的历史，但直到最近，人们才开始关注铁对肠道黏液层的生物学影响，这是由于人们对这种物质在免疫防御中的作用的认识不断发展。黏液层由肠道杯状细胞分泌，覆盖在肠道上皮细胞上，由于其独特的位置，宿主与肠道微生物群以及微生物群之间的相互作用经常发生在黏液层内。铁作为绝大多数生命形式的必需营养素，从宿主和微生物两个角度调节免疫反应。在这篇综述中，我们总结了宿主和肠道微生物群的铁代谢，并描述了铁如何通过肠道黏液层促进肠道黏膜稳态，包括对宿主和肠道共生菌群的影响。本文所描述的发现为铁介导的肠道黏膜屏障功能提供了一个新的视角。
