Hatanaka Sho, Shida Takashi, Osuka Yosuke, Kojima Narumi, Motokawa Keiko, Okamura Tsuyoshi, Hirano Hirohiko, Awata Shuichi, Sasai Hiroyuki
Research Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo, 173-0015, Japan; Integrated Research Initiative for Living Well with Dementia, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo, 173-0015, Japan.
Research Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Itabashi, Tokyo, 173-0015, Japan.
Clin Nutr ESPEN. 2024 Dec;64:114-121. doi: 10.1016/j.clnesp.2024.09.017. Epub 2024 Sep 26.
BACKGROUND & AIM: Bioelectrical impedance analysis-derived phase angle (PhA) reflects the disruption of the cell membrane and intra- and extracellular fluid imbalances caused by chronic inflammation. This study examined the association between PhA and inflammatory markers in community-dwelling older adults.
A sex-stratified logistic regression analysis was conducted, with elevated C-reactive protein (CRP; ≥3.0 mg/L) and interleukin-6 (IL-6; >4.0 pg/mL) levels as the outcomes and whole-body and local PhAs as the exposures. The same analysis was conducted with further stratification for age, overweight status, history of inflammation-related non-communicable diseases, and dietary inflammatory index. The ability to identify inflammation in whole-body and local PhAs was assessed using a receiver operating characteristic (ROC) curve.
This study included 1664 participants (age: 76 [73-80] years; 855 women). In men, significant odds ratios (ORs) at the 95 % confidence interval (95 % CI) were observed for abnormal CRP and IL-6 levels for both whole-body and leg PhAs in the third quartile compared with the lowest quartile (OR [95 % CI] for abnormal CRP levels: 0.36 [0.18, 0.68] for whole-body PhA, 0.51 [0.27, 0.95] for leg PhA; OR [95 % CI] for abnormal IL-6 levels: 0.36 [0.15, 0.81] for whole-body PhA, 0.33 [0.12, 0.78] for leg PhA). The areas under the ROC curves (95 % CI) for identifying abnormal IL-6 were mild in men (0.62 [0.54, 0.70] for whole-body PhA and 0.62 [0.55, 0.70] for leg PhA). In men without a history of inflammation-related non-communicable diseases, it was 0.72 (0.59, 0.85) for whole-body PhA and 0.68 (0.54, 0.81) for leg PhA. In women, the PhA was not significantly associated with inflammatory markers.
PhA is associated with inflammation in community-dwelling older men, but may need to be combined with other information to identify inflammation.
生物电阻抗分析得出的相位角（PhA）反映了慢性炎症引起的细胞膜破坏以及细胞内和细胞外液失衡。本研究调查了社区居住的老年人中PhA与炎症标志物之间的关联。
进行了性别分层的逻辑回归分析，以C反应蛋白（CRP；≥3.0mg/L）和白细胞介素-6（IL-6；>4.0pg/mL）水平升高作为结局，全身和局部PhA作为暴露因素。对年龄、超重状态、炎症相关非传染性疾病史和饮食炎症指数进行进一步分层后进行同样的分析。使用受试者工作特征（ROC）曲线评估全身和局部PhA识别炎症的能力。
本研究纳入了1664名参与者（年龄：76[73 - 80]岁；855名女性）。在男性中，与最低四分位数相比，第三四分位数的全身和腿部PhA在95%置信区间（95%CI）下，CRP和IL-6水平异常的显著优势比（OR）被观察到（CRP水平异常的OR[95%CI]：全身PhA为0.36[0.18, 0.68]，腿部PhA为0.51[0.27, 0.95]；IL-6水平异常的OR[95%CI]：全身PhA为0.36[0.15, 则为0.81]，腿部PhA为0.33[0.12, 0.78]）。男性中识别异常IL-6的ROC曲线下面积（95%CI）为轻度（全身PhA为0.62[0.54, 0.70]，腿部PhA为0.62[0.55, 0.70]）。在没有炎症相关非传染性疾病史的男性中，全身PhA为0.72（0.59, 0.85），腿部PhA为0.68（0.54, 0.81）。在女性中，PhA与炎症标志物无显著关联。
PhA与社区居住的老年男性的炎症相关，但可能需要结合其他信息来识别炎症。
