Barrea Luigi, Muscogiuri Giovanna, Pugliese Gabriella, Laudisio Daniela, de Alteriis Giulia, Graziadio Chiara, Colao Annamaria, Savastano Silvia
Centro Direzionale, Dipartimento di Scienze Umanistiche, Università Telematica Pegaso, Via Porzio, Isola F2, 80143 Napoli, Italy.
Centro Italiano per la Cura e il Benessere del Paziente con Obesità (C.I.B.O), Endocrinology Unit, Department of Clinical Medicine and Surgery, University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
Nutrients. 2021 Apr 24;13(5):1446. doi: 10.3390/nu13051446.
Phase angle (PhA), a noninvasive bioimpedance marker, is a useful tool for nutritional screening in several diseases. C-reactive protein (CRP), a strong risk factor for metabolic and cardiovascular diseases, is a commonly used biomarker of meta-inflammation. As both PhA and CRP are influenced by age, BMI, and nutritional status, and exhibit a clear sex dimorphism, we examined the association between PhA and CRP levels in 1855 subjects (680 males and 1175 females), aged 18-59 years, with BMIs ranging from 19.5 to 69.4 kg/m, stratified according to sex. PhA values and CRP levels were significantly lower in females than males ( < 0.001), while the adherence to the Mediterranean diet (MD) was lower in males compared to females ( < 0.001). After adjusting for age, physical activity, BMI, waist circumference, and adherence to the MD, PhA remained negatively associated with CRP levels in both genders ( < 0.001). In the ROC analysis, PhA ≤ 5.5° in males and ≤5.4° in females were the threshold values predicting increased hs-CRP levels. These results suggested that PhA might represent a valid predictor of CRP levels in both sexes regardless of body weight and adherence to the MD, which avoids the collection of blood sampling and expensive biochemical assays.
相位角（PhA）是一种非侵入性生物阻抗标志物，是多种疾病营养筛查的有用工具。C反应蛋白（CRP）是代谢和心血管疾病的重要危险因素，是常用的亚炎症生物标志物。由于PhA和CRP均受年龄、体重指数（BMI）和营养状况影响，且呈现明显的性别差异，我们在1855名年龄在18至59岁、BMI范围为19.5至69.4kg/m²的受试者（680名男性和1175名女性）中，按性别分层研究了PhA与CRP水平之间的关联。女性的PhA值和CRP水平显著低于男性（P<0.001），而男性对地中海饮食（MD）的依从性低于女性（P<0.001）。在调整年龄、身体活动、BMI、腰围和对MD的依从性后，PhA在两性中仍与CRP水平呈负相关（P<0.001）。在ROC分析中，男性PhA≤5.5°和女性PhA≤5.4°是预测高敏CRP水平升高的阈值。这些结果表明，无论体重和对MD的依从性如何，PhA可能是两性CRP水平的有效预测指标，这避免了采血和昂贵的生化检测。
