Torres Grasiela, Salladay-Perez Ivan A, Dhingra Anika, Covarrubias Anthony J
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Molecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Trends Genet. 2024 Dec;40(12):1018-1031. doi: 10.1016/j.tig.2024.08.007. Epub 2024 Sep 27.
This review comprehensively examines the molecular biology and genetic origins of cellular senescence. We focus on various cellular stressors and pathways leading to senescence, including recent advances in the understanding of the genetic influences driving senescence, such as telomere attrition, chemotherapy-induced DNA damage, pathogens, oncogene activation, and cellular and metabolic stress. This review also highlights the complex interplay of various signaling and metabolic pathways involved in cellular senescence and provides insights into potential therapeutic targets for aging-related diseases. Furthermore, this review outlines future research directions to deepen our understanding of senescence biology and develop effective interventions targeting senescent cells (SnCs).
本综述全面研究了细胞衰老的分子生物学和遗传起源。我们关注导致衰老的各种细胞应激源和途径，包括在理解驱动衰老的遗传影响方面的最新进展，如端粒磨损、化疗诱导的DNA损伤、病原体、癌基因激活以及细胞和代谢应激。本综述还强调了细胞衰老过程中涉及的各种信号传导和代谢途径之间的复杂相互作用，并为衰老相关疾病的潜在治疗靶点提供了见解。此外，本综述概述了未来的研究方向，以加深我们对衰老生物学的理解，并开发针对衰老细胞（SnCs）的有效干预措施。
