Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Sci Rep. 2024 Sep 28;14(1):22453. doi: 10.1038/s41598-024-73184-3.
Endoscopic ultrasound-guided fine needle biopsy is an effective method for obtaining tissue samples from various organs; however, challenges such as inadequate specimens persist. This study compared a newly designed Tricore needle with a Franseen needle for endoscopic ultrasound-guided fine needle biopsy of porcine liver. Both needles were tested on four male Yorkshire pigs. Specimens were obtained with an 100% (36/36) success rate with no procedure-related adverse effects. The Tricore needle experienced significantly less resistance during puncture than Franseen needle (3.83 vs. 5.97 N, P < 0.001) and better ultrasound visibility (168.97 vs. 125.04, P = 0.004). The Tricore needle also achieved faster specimen acquisition time (48.94 vs. 59.90 s, P = 0.038), larger total specimen area (6.67 vs. 4.68 mm, P = 0.049), fewer fragments (23.94 vs. 31.94, P = 0.190), lager fragment area (0.28 vs. 0.15 mm, P < 0.001), and more the number of complete portal tracts (15.44 vs. 9.33, P = 0.017) compared to the Franseen needle. The newly designed Tricore needle showed enhanced procedural performance and specimen quantity and quality compared to commercially available Franseen needle. Although further clinical studies are required, the Tricore needle may represent a favorable option for endoscopic ultrasound-guided fine-needle biopsy procedures.
经内镜超声引导细针活检是一种从各种器官获取组织样本的有效方法；然而，仍然存在标本不足等挑战。本研究比较了一种新设计的 Tricore 针和 Franseen 针在猪肝脏经内镜超声引导细针活检中的应用。两种针均在 4 只雄性约克夏猪上进行了测试。均以 100%（36/36）的成功率获得标本，无与操作相关的不良事件。Tricore 针在穿刺过程中的阻力明显小于 Franseen 针（3.83 比 5.97 N，P<0.001），且超声可视性更好（168.97 比 125.04，P=0.004）。Tricore 针还获得了更快的标本采集时间（48.94 比 59.90 s，P=0.038）、更大的总标本面积（6.67 比 4.68 mm，P=0.049）、更少的碎片（23.94 比 31.94，P=0.190）、更大的碎片面积（0.28 比 0.15 mm，P<0.001），以及更多的完整门脉道（15.44 比 9.33，P=0.017）。与商用的 Franseen 针相比，新设计的 Tricore 针在操作性能、标本数量和质量方面均有改善。尽管还需要进一步的临床研究，但 Tricore 针可能是经内镜超声引导细针活检的一种有利选择。
