Department of Pediatrics, Universidad de La Sabana, Chía, Colombia.
Neonatal Intensive Care Unit, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.
BMC Pediatr. 2024 Sep 28;24(1):609. doi: 10.1186/s12887-024-05059-5.
Cerebral blood flow dynamics can be explored through analysis of endothelial frequencies. Our hypothesis posits a disparity in endothelial activity among neonates with perinatal asphyxia, stratified by the presence or absence of neuronal lesions.
We conducted a retrospective longitudinal study involving newborns treated with hypothermia for moderate to severe asphyxia. Participants were grouped based on the presence or absence of neuronal damage to investigate temporal endothelial involvement in cerebral blood flow regulation. Regional cerebral oxygen saturation (rScO2) was measured using near-infrared spectroscopy (NIRS), and temporal series were analyzed in the frequency domain, utilizing the original frequency of the INVOS™ device.
The study included 88 patients, with 53% (47/88) being male and 33% (29/88) demonstrating brain lesions on magnetic resonance imaging. Among them, 86% (76/88) had a gestational age exceeding 37 weeks according to the Ballard scale, and 81% (71/88) had a birth weight exceeding 2500 g. Cohen's d effect size was calculated to assess differences in endothelial frequency between groups, indicating a small effect size based on cerebral MRI findings (Cohen's d values for Day 2 = 0.2351 and Day 3 = 0.2325).
NIRS represents a valuable tool for monitoring cerebral autoregulation in neonates affected by perinatal asphyxia, underscoring the utility of assessing endothelial frequency or energy on rScO2 measured by NIRS using the original INVOS™ device frequency.
通过分析内皮细胞频率，可以探索脑血流动力学。我们的假设是，存在或不存在神经元损伤的围产期窒息新生儿的内皮细胞活性存在差异。
我们进行了一项回顾性纵向研究，涉及接受低温治疗的中重度窒息新生儿。根据是否存在神经元损伤将参与者分为两组，以研究内皮细胞在脑血流调节中的时间参与情况。使用近红外光谱（NIRS）测量局部脑氧饱和度（rScO2），并在频域中分析时间序列，利用 INVOS™设备的原始频率。
该研究纳入了 88 例患者，其中 53%（47/88）为男性，33%（29/88）在磁共振成像上显示有脑损伤。其中，86%（76/88）根据 Ballard 评分胎龄超过 37 周，81%（71/88）出生体重超过 2500g。计算了 Cohen's d 效应量来评估两组之间内皮细胞频率的差异，根据脑 MRI 结果，提示存在小的效应量（第 2 天的 Cohen's d 值为 0.2351，第 3 天的 Cohen's d 值为 0.2325）。
NIRS 是监测围产期窒息新生儿脑自动调节的一种有价值的工具，强调使用原始 INVOS™设备频率评估 rScO2 上的内皮细胞频率或能量在 NIRS 中的应用。
