早期肺癌患者的呼吸练习：一项荟萃分析。

Breathing exercises for patients with early-stage lung cancer: a meta-analysis.

机构信息

Department of Thoracic Surgery, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, China.

Department of Surgery, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University; Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, No. 1558 Sanhuan north road, Wuxing district, Huzhou, Zhejiang province, 313000, China.

出版信息

Syst Rev. 2024 Sep 28;13(1):243. doi: 10.1186/s13643-024-02640-y.

DOI:10.1186/s13643-024-02640-y

PMID:39342304

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11438133/

Abstract

BACKGROUND

Postoperative pneumonia is a common but serious complication in patients with lung cancer. This meta-analysis aims to evaluate the effect of respiratory exercise on reducing postoperative pneumonia in patients with lung cancer and to provide a reliable basis for clinical treatment and nursing of patients with lung cancer.

METHODS

Two reviewers searched PubMed, Embase, Web of Science, Cochrane Library, China Knowledge Network, Wanfang, and Weipu databases. We searched for the randomized controlled trials (RCTs) published in Chinese or English on the breathing exercises in patients with lung cancer up to January 30, 2024. The quality of the literature was evaluated with the Cochrane Risk of Bias Tool 2 (ROB 2). RevMan 5.3 software was used for meta-analysis.

RESULTS

Eleven RCTs with 1429 patients with lung cancer were included, and 710 patients received breathing exercises. The meta-analysis results showed that breathing exercises could significantly reduce the incidence of postoperative pneumonia [RR = 0.35, 95%CI (0.25, 0.51)], improve the FEV1 [MD = - 0.49, 95%CI (- 0.73, - 0.24)], FVC [MD = - 0.59, 95%CI (- 0.83, - 0.35)] in patients with lung cancer (all P < 0.05). There were significant differences in the incidence of pneumonia for patients undergoing breathing exercises with single exercise time ≥ 15 min (RR = 0.37, 95%CI 0.24 ~ 0.62), breathing exercises for 1 week (RR = 0.29, 95%CI 0.16 ~ 0.55) or for 2 weeks (RR = 0.48, 95%CI 0.28 ~ 0.85) and breathing exercises > 4 times (RR = 0.36, 95%CI 0.23 ~ 0.57) per day (all P < 0.05).

CONCLUSION

Breathing exercises have shown the capacity to augment pulmonary function in patients with lung cancer, concurrently mitigating the risk of postoperative pneumonia.

摘要

背景

术后肺炎是肺癌患者常见但严重的并发症。本荟萃分析旨在评估呼吸锻炼对降低肺癌患者术后肺炎的影响，为肺癌患者的临床治疗和护理提供可靠依据。

方法

两位评审员检索了 PubMed、Embase、Web of Science、Cochrane Library、中国知网、万方和维普数据库，检索了截至 2024 年 1 月 30 日发表的关于肺癌患者呼吸锻炼的中英文随机对照试验（RCT）。使用 Cochrane 偏倚风险工具 2（ROB 2）评价文献质量。使用 RevMan 5.3 软件进行荟萃分析。

结果

纳入 11 项 RCT，共 1429 例肺癌患者，710 例患者接受呼吸锻炼。荟萃分析结果显示，呼吸锻炼可显著降低术后肺炎发生率[RR=0.35，95%CI（0.25，0.51）]，改善 FEV1[MD=−0.49，95%CI（−0.73，−0.24）]和 FVC[MD=−0.59，95%CI（−0.83，−0.35）]（均 P<0.05）。对于单一锻炼时间≥15min（RR=0.37，95%CI 0.24~~0.62）、锻炼 1 周（RR=0.29，95%CI 0.16~~0.55）或 2 周（RR=0.48，95%CI 0.28~~0.85）、每天锻炼次数>4 次（RR=0.36，95%CI 0.23~~0.57）的患者，肺炎发生率差异均有统计学意义（均 P<0.05）。