Sella Tal, Sorouri Kimia, Rosenberg Shoshana M, Loucks Maggie, Kirkner Gregory, Snow Craig, Ruddy Kathryn J, Gelber Shari I, Tamimi Rulla M, Peppercorn Jeffrey M, Schapira Lidia, Borges Virginia F, Come Steven E, Warner Ellen, Partridge Ann H
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, Massachusetts, USA.
Cancer. 2025 Jan 1;131(1):e35585. doi: 10.1002/cncr.35585. Epub 2024 Sep 29.
Following breast cancer (BC), many young women are interested in future childbearing and some may wish to breastfeed. However, limited information is available regarding their lactation experiences.
Participants in the Young Women's Breast Cancer Study, a multicenter, prospective cohort study of women ≤40 years diagnosed with stage 0-III BC between 2006-2016 and who reported one or more live births following diagnosis, were surveyed about pregnancy and breastfeeding after BC treatment, including reasons for attempting and stopping breastfeeding, satisfaction, and supports.
Of 143 eligible women sent a survey, 115 responded and 94 were included in the analytic cohort. Breastfeeding was attempted by 55% of women (52 of 94). Among those who had not attempted, 93% noted prior bilateral mastectomies (39 of 42). Among those who attempted breastfeeding, 69% had undergone lumpectomy and radiotherapy (36 of 52), 83% of whom reported no milk production from their treated breast (30 of 36). Most (65%, 34 of 52) were at least somewhat satisfied with their ability to breastfeed. Reasons for stopping breastfeeding included: having completed the planned duration (36%, 19 of 52); to start/resume endocrine therapy (21%, 11 of 52); and to resume breast imaging (8%, 4 of 52). Approximately half (27 of 55) of women who had not undergone bilateral mastectomies recalled receiving specific information about breastfeeding after BC, mostly from the oncology team (59%, 16 of 27), online resources (48%, 13 of 27), or a lactation consultant (44%, 12 of 27).
Most young BC survivors who attempted to breastfeed were able to and were satisfied with the experience, despite challenges. Specific resources to support BC survivors who wish to breastfeed are needed.
乳腺癌（BC）患者中，许多年轻女性对未来生育感兴趣，部分人可能希望进行母乳喂养。然而，关于她们哺乳经历的信息有限。
“年轻女性乳腺癌研究”的参与者为2006年至2016年间确诊为0 - III期乳腺癌且年龄≤40岁的女性，该研究为多中心前瞻性队列研究，这些女性在确诊后报告有一次或多次活产。对她们进行了关于乳腺癌治疗后怀孕和母乳喂养的调查，包括尝试和停止母乳喂养的原因、满意度及支持情况。
在143名符合条件并收到调查问卷的女性中，115人回复，94人被纳入分析队列。55%的女性（94人中的52人）尝试进行母乳喂养。在未尝试母乳喂养的女性中，93%表示之前接受过双侧乳房切除术（共42人，其中39人）。在尝试母乳喂养的女性中，69%接受过肿块切除术和放疗（52人中的36人），其中83%报告患侧乳房无乳汁分泌（36人中的30人）。大多数（65%，52人中的34人）对自己的母乳喂养能力至少有些满意。停止母乳喂养的原因包括：已达到计划的持续时间（36%，52人中的19人）；开始/恢复内分泌治疗（21%，52人中的11人）；恢复乳房影像学检查（8%，52人中的4人）。在未接受双侧乳房切除术（共55人）的女性中，约一半（27人）回忆起在乳腺癌治疗后收到过关于母乳喂养的具体信息，大部分来自肿瘤学团队（59%，27人中的16人）、网络资源（48%，27人中的13人）或哺乳顾问（44%，27人中的12人）。
尽管存在挑战，但大多数尝试母乳喂养的年轻乳腺癌幸存者能够做到并对这段经历感到满意。需要有专门的资源来支持希望进行母乳喂养的乳腺癌幸存者。
