School of Textile and Garment, Anhui Polytechnic University, Wuhu, Anhui 241000, China.
School of Textile and Garment, Anhui Polytechnic University, Wuhu, Anhui 241000, China; Guangzhou Jingwei Jinfang Protection Technology Co., Ltd, Guangzhou 510000, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2025 Feb 5;326:125192. doi: 10.1016/j.saa.2024.125192. Epub 2024 Sep 23.
Glucose is a key biomarker of diabetes, and effective glucose monitoring methods are crucial to the prevention and management of diabetes. Therefore, in this paper, FeO/DEX/PDA@Au (Raman reporters) @Au nanocomposites were synthetized that with DTNB (5,5'-dithiobis(2-nitrobenzoic)), MMTA (2-mercapto-4-methyl-5-thiazole acetic acid), MBA (4-mercaptobenzoic acid) and 4-Mpy(4-Mercaptopyridine) were used separately as Raman reporters. FeO and PDA (Polymerized dopamine) could supply more high surface area of active sites and high SERS (Surface-Enhanced Raman Scattering) substrate, which has high stability and reproducibility. Dextran coating is an effective way to prepare biocompatible materials TEM, XRD, TG and VSM were used to analyze the size, morphology and magnetic properties of the nanocomposites. FeO/DEX/PDA@Au(Raman reporters)@Au that integrates a multi-hotspot structure and magnetic separation techniques were studied the enhancement effect of Raman spectra, and glucose solutions with different concentrations were tested. Furthermore, the optimal FeO/DEX/PDA@Au(Raman reporters)@Au nanocomposites were supplied as SERS substrates for detection of glucose accurately and quickly in sweat. SERS signal intensity is linearly correlated with glucose concentration within the measurement range of 5 × 10 to 10 mM, and the minimum detectable concentration is 5 µM. The FeO/DEX/PDA@Au(Raman reporters)@Au nanocomposites exhibit high reliability, specificity and repeatability of the strategy were then verified by practical detection of sweat.
葡萄糖是糖尿病的一个关键生物标志物，有效的葡萄糖监测方法对于糖尿病的预防和管理至关重要。因此，在本文中，我们合成了 FeO/DEX/PDA@Au（拉曼报告分子）@Au 纳米复合材料，分别使用 DTNB（5,5'-二硫代双（2-硝基苯甲酸））、MMTA（2-巯基-4-甲基-5-噻唑乙酸）、MBA（4-巯基苯甲酸）和 4-Mpy（4-巯基吡啶）作为拉曼报告分子。FeO 和 PDA（聚多巴胺）可以提供更多的高表面积活性位点和高 SERS（表面增强拉曼散射）基底，具有高稳定性和重现性。葡聚糖涂层是制备生物相容性材料的有效方法。TEM、XRD、TG 和 VSM 用于分析纳米复合材料的尺寸、形貌和磁性能。我们研究了具有多热点结构和磁分离技术的 FeO/DEX/PDA@Au（拉曼报告分子）@Au 对拉曼光谱的增强效果，并测试了不同浓度的葡萄糖溶液。此外，我们提供了最佳的 FeO/DEX/PDA@Au（拉曼报告分子）@Au 纳米复合材料作为 SERS 基底，用于快速准确地检测汗水中的葡萄糖。SERS 信号强度与测量范围内 5×10 到 10 mM 的葡萄糖浓度呈线性相关，最低检测浓度为 5 µM。FeO/DEX/PDA@Au（拉曼报告分子）@Au 纳米复合材料表现出高可靠性、特异性和重复性，然后通过实际检测汗液来验证该策略的可靠性。
