de la Maza L M, Peterson E M, Fennie C W, Czarniecki C W
J Immunol. 1985 Dec;135(6):4198-200.
The effect of recombinant murine interferon-gamma on the growth of Chlamydia trachomatis was analyzed in a mouse fibroblast cell line (McCoy cells). Murine interferon-gamma had a very potent anti-chlamydial activity, although minimally affecting cellular proliferation. Over 95% inhibition of chlamydial inclusions was obtained at a concentration of 1 U/ml of interferon. At a concentration of 1 U/ml of murine interferon-gamma, there was minimal inhibition of the proliferative capacity of McCoy cells. Approximately 50% inhibition of cell growth was obtained with a concentration of 10 U/ml of interferon. Varying concentrations of tryptophan in the medium did not alter either the anti-chlamydial or the anti-proliferative activity of the interferon.
在小鼠成纤维细胞系（McCoy细胞）中分析了重组鼠γ干扰素对沙眼衣原体生长的影响。鼠γ干扰素具有非常强的抗衣原体活性，尽管对细胞增殖的影响极小。在干扰素浓度为1 U/ml时，超过95%的衣原体包涵体受到抑制。在鼠γ干扰素浓度为1 U/ml时，McCoy细胞增殖能力的抑制作用极小。在干扰素浓度为10 U/ml时，细胞生长受到约50%的抑制。培养基中不同浓度的色氨酸既不改变干扰素的抗衣原体活性，也不改变其抗增殖活性。
