Sotoodeh Adonis, Hedberg Pontus, Granath Fredrik, Alfvén Tobias, Nauclér Pontus
Division of Infectious Diseases, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.
Vaccine. 2024 Dec 2;42(26):126388. doi: 10.1016/j.vaccine.2024.126388. Epub 2024 Sep 28.
Limited data exists on sociodemographic differences in vaccination coverage against COVID-19 among adolescents. This study investigated the association of sociodemographic factors and vaccination coverage of adolescents aged 12 to 17 years over the period of the general vaccination recommendation in Stockholm County, Sweden.
We conducted a population-based retrospective cross-sectional study of vaccine uptake of at least one dose of a COVID-19 vaccine up until 31 October 2022. We analysed vaccination coverage by sex, age group, underlying medical conditions, household socioeconomic factors, and vaccination status among adults in the household, using stratified analyses and multivariable modified Poisson regression models.
The study cohort consisted of 166,634 adolescents out of which 70.3 % (n = 117,185) received at least one dose of a COVID-19 vaccine. In the fully adjusted model, the strongest predictor for not being vaccinated was if all adults in the household were unvaccinated (adjusted relative risk, aRR, 0.11, 95 % CI 0.10-0.12). Lower household education level and having both parents born outside Sweden were similarly negatively associated with vaccination coverage among adolescents. No association was observed between vaccination coverage and being an adolescent with an underlying medical condition (aRR 1.00, 95 % CI 0.99-1.02).
Our results emphasise the necessity to address sociodemographic disparities and to engage adolescents at risk through targeted measures with particular emphasis in low-vaccination households in addition to households with lower education and non-Swedish origins in future vaccination program strategies.
关于青少年新冠疫苗接种覆盖率的社会人口学差异的数据有限。本研究调查了瑞典斯德哥尔摩郡在一般疫苗接种建议期间,社会人口学因素与12至17岁青少年疫苗接种覆盖率之间的关联。
我们进行了一项基于人群的回顾性横断面研究,统计截至2022年10月31日至少接种一剂新冠疫苗的情况。我们通过性别、年龄组、基础疾病、家庭社会经济因素以及家庭中成年人的疫苗接种状况分析疫苗接种覆盖率,采用分层分析和多变量修正泊松回归模型。
研究队列包括166,634名青少年,其中70.3%(n = 117,185)接种了至少一剂新冠疫苗。在完全调整模型中,未接种疫苗的最强预测因素是家庭中的所有成年人都未接种疫苗(调整相对风险,aRR,0.11,95%可信区间0.10 - 0.12)。较低的家庭教育水平以及父母双方均出生在瑞典境外同样与青少年的疫苗接种覆盖率呈负相关。未观察到疫苗接种覆盖率与患有基础疾病的青少年之间存在关联(aRR 1.00,95%可信区间0.99 - 1.02)。
我们的结果强调了在未来的疫苗接种计划策略中,有必要解决社会人口学差异问题,并通过有针对性的措施让有风险的青少年参与进来,尤其要重点关注低疫苗接种率家庭以及教育程度较低和非瑞典裔家庭。