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编辑评论:髋关节软骨修复的理想治疗方案仍然难以捉摸,需要考虑个体患者因素。

Editorial Commentary: The Ideal Treatment Option for Hip Cartilage Repair Remains Elusive and Requires Consideration of Individual Patient Factors.

作者信息

Zimmerer Alexander

出版信息

Arthroscopy. 2025 Apr;41(4):1153-1154. doi: 10.1016/j.arthro.2024.09.044. Epub 2024 Sep 27.

DOI:10.1016/j.arthro.2024.09.044
PMID:39343076
Abstract

Arthroscopic treatment of hip chondral lesions is a challenge. Recent research shows arthroscopic debridement with preservation of the subchondral bone plate shows superior results compared with microfracture. The results of microfracture can be unpredictable, largely because of the formation of fibrocartilage, which lacks the durability of hyaline cartilage. Autologous matrix-induced chondrogenesis has emerged as a promising alternative. This technique combines microfracture or abrasion with the application of a collagen membrane and aims to enhance the quality of the repair tissue. Autologous matrix-induced chondrogenesis not only improves patient-reported outcomes but also decreases the rate of conversion to total hip arthroplasty when compared with microfracture. Yet, the results remain only fair and variable. Autologous chondrocyte implantation, which involves the cultivation and reimplantation of chondrocytes, although more labor-intensive, may lead to a more robust and durable repair. In addition, newer methods like minced cartilage implantation show encouraging early results. We are in the early stages of understanding cartilage repair, and individual patient factors, such as size of the lesion, patient age, activity level, and coexisting conditions all require consideration.

摘要

髋关节软骨损伤的关节镜治疗是一项挑战。最近的研究表明,与微骨折相比,保留软骨下骨板的关节镜清创术显示出更好的效果。微骨折的结果可能不可预测,这主要是因为纤维软骨的形成,而纤维软骨缺乏透明软骨的耐久性。自体基质诱导软骨形成已成为一种有前景的替代方法。该技术将微骨折或磨削与胶原膜的应用相结合,旨在提高修复组织的质量。与微骨折相比,自体基质诱导软骨形成不仅改善了患者报告的结果,还降低了全髋关节置换术的转换率。然而,结果仍然只是一般且存在差异。自体软骨细胞植入涉及软骨细胞的培养和再植入,虽然劳动强度更大,但可能导致更强大和持久的修复。此外,像碎软骨植入等更新的方法显示出令人鼓舞的早期结果。我们对软骨修复的理解尚处于早期阶段,个体患者因素,如损伤大小、患者年龄、活动水平和并存疾病等都需要考虑。

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