Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
J Clin Exp Hematop. 2024;64(3):156-165. doi: 10.3960/jslrt.24031.
Histiocytic neoplasms (HNs) include juvenile xanthogranuloma, Erdheim-Chester disease, Rosai-Dorfman disease, ALK-positive histiocytosis, and histiocytic sarcoma in the 5th edition of the World Health Organization Classification of Haematolymphoid Tumours. These entities are clinicopathologically distinctive, and typical histological findings have been established. However, the common feature of a proliferation of histiocytic cells often leads to morphological overlap among HNs, and also necessitates a differential diagnosis from several non-HNs or non-neoplastic conditions. In this review, we provide a brief summary of the clinical findings, molecular features, histopathologies, and immunophenotypes of HNs, as well as to discuss their differential diagnosis.
组织细胞肿瘤（HNs）包括在第五版世界卫生组织血液淋巴组织肿瘤分类中的幼年黄色肉芽肿、Erdheim-Chester 病、Rosai-Dorfman 病、ALK 阳性组织细胞增生症和组织细胞肉瘤。这些实体在临床病理上具有特征性，已经建立了典型的组织学发现。然而，组织细胞增殖的共同特征往往导致 HNs 之间存在形态学重叠，也需要与几种非 HNs 或非肿瘤性疾病进行鉴别诊断。在这篇综述中，我们简要总结了 HNs 的临床发现、分子特征、组织病理学和免疫表型，并讨论了它们的鉴别诊断。
