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探索特应性皮炎中的相互作用：肥胖、脂质代谢与临床表现

Exploring the Interplay: Obesity, Lipid Metabolism, and Clinical Manifestations in Atopic Dermatitis.

作者信息

Chu Howard, Jung Yeon Woo, Kim Su Min, Bae Byung Gi, Bae Jung Min, Kim Lark Kyun, Lee Kwang Hoon, Park Chang Ook

机构信息

Department of Dermatology, Severance Hospital and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Department of Biomedical Sciences, Graduate School of Medical Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Ann Dermatol. 2024 Oct;36(5):310-317. doi: 10.5021/ad.23.151.

DOI:10.5021/ad.23.151
PMID:39343758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11439982/
Abstract

BACKGROUND

The interest toward the association between atopic dermatitis (AD) and obesity is increasing, yet the possibility of abnormal lipid metabolism has never been investigated before.

OBJECTIVE

To identify the characteristics of patients with AD who are obese and analyze the serum lipid profiles of these patients.

METHODS

This observational study included 167 patients diagnosed with AD and underwent evaluations for serum lipid panels between July 2017 and October 2017. The patients' body mass index was used to determine obesity and the serum lipid panels were analyzed between patients who are obese and non-obese. Also, the disease severity and subjective symptoms were evaluated and serum total immunoglobulin E (IgE) and specific IgE levels were assessed.

RESULTS

Of the 167 patients with AD, there were 36 obese and 131 non-obese subjects. Obese patients were found to have a significantly higher disease severity, as well as higher serum triglyceride and low-density lipoprotein-cholesterol levels and lower high-density lipoprotein-cholesterol levels, which was most pronounced in adult males. Obesity AD patients also had a significantly higher serum total IgE, itch intensity score, and number of allergens sensitized.

CONCLUSION

Patients with AD who are obese should be monitored for possible abnormalities in lipid metabolism. Obesity may be a factor that contributes to a higher disease severity of AD.

摘要

背景

对特应性皮炎（AD）与肥胖之间关联的关注度日益增加，但脂质代谢异常的可能性此前从未被研究过。

目的

确定肥胖的AD患者的特征，并分析这些患者的血脂谱。

方法

这项观察性研究纳入了167例在2017年7月至2017年10月期间被诊断为AD并接受血脂检测评估的患者。采用患者的体重指数来确定肥胖情况，并对肥胖和非肥胖患者的血脂谱进行分析。此外，评估疾病严重程度和主观症状，并检测血清总免疫球蛋白E（IgE）和特异性IgE水平。

结果

在167例AD患者中，有36例肥胖患者和131例非肥胖患者。发现肥胖患者的疾病严重程度显著更高，血清甘油三酯和低密度脂蛋白胆固醇水平更高，高密度脂蛋白胆固醇水平更低，这在成年男性中最为明显。肥胖的AD患者血清总IgE、瘙痒强度评分和致敏变应原数量也显著更高。

结论

应监测肥胖的AD患者是否存在脂质代谢异常。肥胖可能是导致AD疾病严重程度更高的一个因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01a6/11439982/7120b692cfb8/ad-36-310-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01a6/11439982/0765d53d9a84/ad-36-310-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01a6/11439982/a013f88b24fb/ad-36-310-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01a6/11439982/5749390b3f2b/ad-36-310-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01a6/11439982/7120b692cfb8/ad-36-310-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01a6/11439982/0765d53d9a84/ad-36-310-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01a6/11439982/a013f88b24fb/ad-36-310-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01a6/11439982/5749390b3f2b/ad-36-310-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01a6/11439982/7120b692cfb8/ad-36-310-g004.jpg

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