Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
Bull Exp Biol Med. 2024 Sep;177(5):626-629. doi: 10.1007/s10517-024-06237-2. Epub 2024 Sep 30.
The anti-inflammatory properties of Bacteroides fragilis vesicles were studied in a rat model of dextran sodium sulfate-induced colitis. According to the histology results, addition of B. fragilis vesicles to the therapy promoted colon repair. Evaluation of the disease activity index confirms the high rate of colon recovery: against the background of vesicle administration, the absence of blood in stool, normal stool consistency, and body weight normalization were observed.
研究了脆弱拟杆菌囊泡在葡聚糖硫酸钠诱导的结肠炎大鼠模型中的抗炎特性。根据组织学结果，添加脆弱拟杆菌囊泡进行治疗可促进结肠修复。疾病活动指数评估证实了结肠的高恢复率：在给予囊泡的背景下，观察到粪便中无血液、粪便稠度正常和体重正常。
