Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Bull Exp Biol Med. 2024 Sep;177(5):616-620. doi: 10.1007/s10517-024-06235-4. Epub 2024 Sep 30.
We studied the relationship of inotropic responses of the isolated myocardium to stimulation of β-and β-adrenergic receptors (β-AR) with echocardiography parameters in 28 patients with coronary heart disease (CHD). Myocardial fragments (trabeculae of the right atrial appendage) were obtained during coronary artery bypass surgery. The inotropic response of the trabeculae was assessed in an isometric mode. Stimulation of β-and β-AR with agonists was performed against the background of preliminary α-AR blockade. In case of preserved ejection fraction, significant inotropic response of the trabeculae (135 (112; 154)% from the initial contraction amplitude) was observed after β-AR stimulation, while in reduced ejection fraction, its significant increase was observed after β-AR stimulation (126 (112; 170)% from the initial contraction amplitude). In patients with preserved and reduced ejection fraction, the correlations between the inotropic responses of the trabeculae to β-and β-AR stimulation and echocardiography parameters were different. The revealed differences reflect the degree of cardiac remodeling under condition of the studied pathology.
我们研究了 28 例冠心病患者（CHD）心肌对β和β肾上腺素能受体（β-AR）刺激的变力反应与超声心动图参数之间的关系。在冠状动脉旁路手术后获得心肌片段（右心房心耳的小梁）。小梁的变力反应在等长模式下进行评估。在预先阻断α-AR 的背景下，用激动剂刺激β和β-AR。在射血分数保留的情况下，观察到β-AR 刺激后小梁的显著变力反应（初始收缩幅度的 135（112；154）%），而在射血分数降低的情况下，观察到β-AR 刺激后其显著增加（初始收缩幅度的 126（112；170）%）。在射血分数保留和降低的患者中，小梁对β和β-AR 刺激的变力反应与超声心动图参数之间的相关性不同。所揭示的差异反映了在研究病理条件下心脏重构的程度。
