School of Medicine, Federal University of Alfenas, Alfenas, MG, Brazil.
Childs Nerv Syst. 2024 Dec;40(12):4115-4121. doi: 10.1007/s00381-024-06635-x. Epub 2024 Sep 30.
This integrative literature review aims to discuss the benefits and limitations of postnatal surgery to correct myelomeningocele using the placenta as an autologous graft used on the lesion; in addition, it seeks to highlight the placental properties and the benefits and indications of surgery.
For this production, the PRISMA criteria were used. PubMed was used as a database on October 19, 2023, and three searches were made, all using the words "myelomeningocele" and "surgery" varying only between "amnion," "placenta," and "chorion" as the third word. A total of 91 articles were found, and after analysis of duplicates and inclusion and exclusion criteria, only 11 articles were used in this systematic review.
Properties of the amniotic membrane were observed, such as anti-inflammatory, stimulation of native tissue growth, regenerating action by the secretion of neutrophil factors, promotion of epithelialization, inhibition of fibrosis and healing, and antibacterial effect. It is observed that there are benefits in using the placenta as an autograft and there are contradictions between the periods of surgery.
Due to its properties that accelerate healing, the absence of the possibility of rejection, and its easy access make this choice more frequently adopted. We are confident in saying that the effectiveness of the amniotic membrane is widely reliable.
本综述旨在讨论利用胎盘作为自体移植物修复脊髓脊膜膨出的益处和局限性；此外，还探讨了胎盘的特性以及手术的益处和适应证。
本研究采用 PRISMA 标准。于 2023 年 10 月 19 日在 PubMed 数据库中检索，共进行了 3 次检索，均使用“脊髓脊膜膨出”和“手术”这两个词，仅第 3 个词分别为“羊膜”“胎盘”和“绒毛膜”。共检索到 91 篇文章，经分析重复和纳入排除标准后，本系统评价仅使用了 11 篇文章。
观察到羊膜的特性，如抗炎、刺激固有组织生长、通过中性粒细胞因子分泌的再生作用、促进上皮化、抑制纤维化和愈合以及抗菌作用。观察到将胎盘用作自体移植物有好处，但手术时期存在争议。
由于其加速愈合的特性、不存在排斥的可能性以及易于获取，这种选择更常被采用。我们有信心地说，羊膜的有效性是广泛可靠的。
