Nussinov R
J Mol Evol. 1985;22(2):150-9. doi: 10.1007/BF02101693.
Calculations of DNA angular parameters in 50 eukaryotic sequences reveal regions of large conformational deviations from ideal DNA around regulatory sites. Frequently, discrete peaks of structural variation are present upstream of genes. Known regulatory regions often include variants of consensus sequences. Thus, imprecise sequences and structures are recognized within large genomic stretches. The existence of structurally "wrinkled" regions in the vicinity of regulatory sequences is likely to facilitate greatly their recognition by proteins and enzymes.
对50个真核生物序列中的DNA角度参数进行计算后发现，调控位点周围存在与理想DNA构象偏差较大的区域。结构变异的离散峰常常出现在基因上游。已知的调控区域通常包含共有序列的变体。因此，在大片段基因组中可识别出不精确的序列和结构。调控序列附近存在结构上“起皱”的区域，这很可能极大地便于蛋白质和酶对它们的识别。
