与理想B-DNA和原核生物调控位点存在较大螺旋构象偏差。

Large helical conformational deviations from ideal B-DNA and prokaryotic regulatory sites.

作者信息

Nussinov R

出版信息

J Theor Biol. 1985 Jul 21;115(2):179-89. doi: 10.1016/s0022-5193(85)80094-1.

PMID:2412072

Abstract

The variations in several double helical DNA angular parameters have been calculated along about 60 bacterial and phage sequences, each several hundreds nucleotides long. Regions of large geometric irregularities are found at, or in the vicinity of, regulatory protein recognition sites. Based on these extensive computations I suggest that these structurally "wrinkled" regions facilitate the first stage of the recognition process.

摘要

沿着大约60个细菌和噬菌体序列（每个序列几百个核苷酸长）计算了几个双螺旋DNA角度参数的变化。在调节蛋白识别位点处或其附近发现了几何不规则性较大的区域。基于这些广泛的计算，我认为这些结构上“起皱”的区域促进了识别过程的第一阶段。