Xin Jianwei, Meng Zihui, Qiao Yu, Zhang Yuqi
School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, China.
College of Medicine, Yan'an University, Yan'an 716000, China.
Anal Methods. 2024 Nov 7;16(43):7366-7371. doi: 10.1039/d4ay01393j.
Sodium dichloroisocyanurate (SDIC) is an efficient, safe and convenient halogen disinfectant that is widely used for hospital, tableware and swimming pool disinfection. In order to ensure its effective use and safety, especially in clinical settings, effective identification methods are necessary. The effective chlorine content is one of the quality standards for chlorine-containing disinfectants, but its complex experimental operation as well as poor specificity and portability limit its application. In contrast, testing based on molecularly imprinted photonic crystal sensors provides excellent performance. Therefore, it is of great significance to establish a new and simple SDIC recognition method. We prepared a novel molecularly imprinted two-dimensional (2D) photonic crystal hydrogel (MIPH) for sensitive and label-free recognition of SDIC. The response performance of the resultant MIPH sensor was determined by monitoring particle spacing changes in the polystyrene (PS) 2D photonic crystals embedded in the hydrogel. Particle spacing changes were recorded by measuring changes in the diameter of the Debye diffraction ring of the MIPH sensor. As the concentration of SDIC in solution increased from 1 × 10 to 1.0 mmol L, the diameter of the Debye diffraction ring increased by 6 mm, and the corresponding photonic crystal particle spacing decreased by 56 nm. The particle spacing changes in the MIPH sensor showed a linear relationship with the SDIC concentration in the range of 1 × 10-1.0 mmol L, and the limit of detection (S/N = 3) was found to be 3 × 10 mmol L. The constructed hydrogel sensor was successfully used to detect SDIC in sodium dichloroisocyanurate disinfectant powder, demonstrating recoveries of 96-100% and RSD of 7.2-7.6%. Our molecularly imprinted SDIC photonic crystal hydrogel provides a universal strategy for designing sensors for other clinical disinfectants.
二氯异氰尿酸钠（SDIC）是一种高效、安全且便捷的卤素消毒剂，广泛应用于医院、餐具及游泳池消毒。为确保其有效使用及安全性，尤其是在临床环境中，有效的识别方法必不可少。有效氯含量是含氯消毒剂的质量标准之一，但其复杂的实验操作以及较差的特异性和便携性限制了其应用。相比之下，基于分子印迹光子晶体传感器的检测具有出色的性能。因此，建立一种新型且简便的SDIC识别方法具有重要意义。我们制备了一种新型分子印迹二维（2D）光子晶体水凝胶（MIPH），用于对SDIC进行灵敏且无标记的识别。通过监测嵌入水凝胶中的聚苯乙烯（PS）二维光子晶体中的粒子间距变化来确定所得MIPH传感器的响应性能。通过测量MIPH传感器的德拜衍射环直径变化来记录粒子间距变化。随着溶液中SDIC浓度从1×10增加到1.0 mmol/L，德拜衍射环直径增加了6 mm，相应的光子晶体粒子间距减小了56 nm。MIPH传感器中的粒子间距变化与1×10 - 1.0 mmol/L范围内的SDIC浓度呈线性关系，检测限（S/N = 3）为3×10 mmol/L。构建的水凝胶传感器成功用于检测二氯异氰尿酸钠消毒粉中的SDIC，回收率为96 - 100%，相对标准偏差为7.2 - 7.6%。我们的分子印迹SDIC光子晶体水凝胶为设计用于其他临床消毒剂的传感器提供了一种通用策略。
