[贝罗福α2（重组人干扰素α2精氨酸）与阿昔洛韦治疗树枝状角膜炎]

[Berofor alpha 2 (r-HUIFN-alpha 2 arg) and acyclovir in the treatment of dendritic keratitis].

作者信息

Meurs P J, van Bijsterveld O P

出版信息

Klin Monbl Augenheilkd. 1985 Jul;187(1):40-2. doi: 10.1055/s-2008-1050985.

DOI:10.1055/s-2008-1050985

Abstract

In a double-masked clinical trial a total of 24 patients have so far been treated with recombinant human alpha 2-interferon in combination with Acyclovir (ACV), and 21 patients with a placebo-Acyclovir combination. Both partial and complete healing times were statistically significantly shortened in the r-Hu IFN-alpha 2-AVC group, by 35 and 32 percent respectively. No difference could be demonstrated between the combination of r-Hu IFN-alpha 2 arg and ACV and that of BCL IFN and ACV as far as the therapeutic effect was concerned. R-Hu IFN-alpha 2 drops in combination with Acyclovir ointment were excellently tolerated.

摘要

在一项双盲临床试验中，迄今为止共有24例患者接受了重组人α2干扰素与阿昔洛韦（ACV）联合治疗，21例患者接受了安慰剂-阿昔洛韦联合治疗。r-Hu IFN-α2-ACV组的部分愈合时间和完全愈合时间均在统计学上显著缩短，分别缩短了35%和32%。就治疗效果而言，r-Hu IFN-α2arg与ACV的联合用药与BCL IFN与ACV的联合用药之间未显示出差异。r-Hu IFN-α2滴眼液与阿昔洛韦软膏联合使用耐受性良好。