Department of Immunization, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Department of Chronic Communicable Disease, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Epidemiol Infect. 2024 Sep 30;152:e105. doi: 10.1017/S095026882400102X.
Varicella is a vaccine-preventable infectious disease. Since 1 December 2018, the varicella vaccine has been included in the local Expanded Programme on Immunization (EPI) in Wuxi, China, and children born after 1 December 2014 are eligible for free vaccination. To evaluate the effect of varicella vaccination in Wuxi city, we selected 382 397 children born from 2012 to 2016 as subjects. Their disease data were obtained from the Chinese Disease Prevention and Control Information System, and their vaccination data were obtained from the Jiangsu Province Vaccination Integrated Service Management Information System. The incidence of breakthrough varicella cases increased in the first 4 years and reached the peak in the fifth year. With the increase of vaccination rate, the incidence of varicella decreased significantly. The vaccine effectiveness (VE) was found to be 88.17%-95.78% for one dose and 98.65%-99.93% for two doses. Although the VE per dose decreased from 99.57% in the first year to 93.04% in the eighth year, it remained high. These findings confirmed the effectiveness of varicella vaccination in children, supported the use of a two-dose varicella vaccination strategy to achieve better protection, and provided important insights into the optimal vaccination strategy for varicella prevention in children.
水痘是一种可通过疫苗预防的传染病。自 2018 年 12 月 1 日起，水痘疫苗已被纳入中国无锡的扩大免疫规划（EPI），2014 年 12 月 1 日后出生的儿童可免费接种该疫苗。为评估水痘疫苗在无锡市的效果，我们选择了 2012 年至 2016 年出生的 382397 名儿童作为研究对象。他们的疾病数据来自中国疾病预防控制信息系统，疫苗接种数据来自江苏省疫苗接种综合服务管理信息系统。突破性水痘病例的发病率在前 4 年呈上升趋势，并在第 5 年达到高峰。随着接种率的增加，水痘发病率显著下降。研究发现，一剂疫苗的疫苗效力（VE）为 88.17%-95.78%，两剂疫苗的 VE 为 98.65%-99.93%。虽然每剂疫苗的 VE 从第 1 年的 99.57%下降到第 8 年的 93.04%，但仍保持较高水平。这些发现证实了水痘疫苗在儿童中的有效性，支持采用两剂水痘疫苗接种策略以实现更好的保护效果，并为儿童水痘预防的最佳接种策略提供了重要见解。
