The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
Department of Clinical Laboratory, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
Appl Environ Microbiol. 2024 Oct 23;90(10):e0135324. doi: 10.1128/aem.01353-24. Epub 2024 Sep 30.
Traditional antibiotics have been effective in many cases. However, the rise in multidrug-resistant bacteria has diminished their therapeutic efficacy, signaling the dawn of an era beyond antibiotics. The challenge of multidrug resistance in is particularly critical, with increasing global mortality and resistance rates. Therefore, the development of alternative therapies to antibiotics is urgently needed. Phages, which are natural predators of bacteria, have inherent advantages. However, comprehensive information on phages is lacking in current literature. This review aims to analyze and summarize relevant studies, focusing on the present state of phage therapy for infections. This includes an examination of treatment methodologies, associated challenges, strategies, new phage technologies, clinical trial safety and efficacy, regulatory issues, and future directions for phage therapy development. Enhancing phage technology is crucial for addressing the evolving threat of multidrug-resistant .
传统抗生素在许多情况下都很有效。然而，多重耐药菌的出现降低了它们的治疗效果，这标志着抗生素时代的结束。 的多重耐药性挑战尤其严峻，全球死亡率和耐药率不断上升。因此，迫切需要开发抗生素的替代疗法。噬菌体作为细菌的天然捕食者，具有内在的优势。然而，目前文献中缺乏关于 噬菌体的全面信息。本综述旨在分析和总结相关研究，重点关注噬菌体治疗 感染的现状。这包括检查治疗方法、相关挑战、策略、新型噬菌体技术、临床试验的安全性和疗效、监管问题以及噬菌体治疗发展的未来方向。增强噬菌体技术对于应对不断演变的多重耐药 威胁至关重要。
