Krottmayer G, Kerbel R, Müller W D, Kurz R
Monatsschr Kinderheilkd. 1985 Oct;133(10):764-6.
This report describes an infant with congenital central hypoventilation. There is no response to 4% CO2-breathing in sleep and in awake state. Hypoxia, behavioral and "behavioral like" inputs increase ventilation, but not to normal levels. Drugs such as theophylline, naloxone, acetazolamide, methylprogesterone, thyroxine and nicethamide have no effect on the respiratory control. Despite the insertion of a phrenic nerve pacemaker intermittent positive pressure ventilation must be provided in addition.
本报告描述了一名患有先天性中枢性低通气的婴儿。在睡眠和清醒状态下，对4%二氧化碳呼吸试验均无反应。缺氧、行为及“类行为”刺激可增加通气，但未达到正常水平。诸如茶碱、纳洛酮、乙酰唑胺、甲羟孕酮、甲状腺素及尼可刹米等药物对呼吸控制均无作用。尽管植入了膈神经起搏器，但仍需额外提供间歇性正压通气。
