Kishimoto Takahiro, Onishi Hidenori, Tsubouchi Hiromasa, Mizukami Yasutaka, Kubota Masafumi, Ikeda Ryouko, Konoshita Naohiro, Tanaka Tokuharu, Kobayashi Koji, Hayashi Hiroyuki, Yamamura Osamu
Department of Family Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1104, Japan.
Department of Radiology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1104, Japan.
J Clin Biochem Nutr. 2024 Sep;75(2):145-152. doi: 10.3164/jcbn.24-58. Epub 2024 May 8.
Neurological and skeletal muscle properties are suggested causes of dynapenia. This study aimed to evaluate the relationship between upper limb muscle quality (grip strength/upper extremity muscle mass) and knee osteoarthritis in dynapenia, and to identify dynapenia-associated factors. Elderly individuals who responded to a public call for screening in Wakasa Town, Fukui Prefecture between June 2019 and November 2021 were included. The analysis included 433 participants (304 women aged 76.0 ± 7.1 years). Examination comprised (consecutively) a basic interview, physical function measurement, body composition measurement, and explanation of results. Dynapenia was observed in 67 patients. Binomial logistic regression analysis revealed that age, upper limb muscle quality score, and knee osteoarthritis were independent factors for dynapenia. Receiver operating characteristic analysis of the relationship between dynapenia and upper limb muscle quality showed an area under the curve of 0.806 (95% confidence interval: 0.658-0.953) for men (cut-off value, 14.3 kg/kg) and 0.849 for women (95% confidence interval: 0.858-0.968; cut-off value, 14.0 kg/kg). In conclusion, age, upper limb muscle quality, and knee osteoarthritis were independent factors of dynapenia. We demonstrated that upper limb muscle quality has good accuracy in detecting dynapenia in both men and women.
神经和骨骼肌特性被认为是导致肌肉减少症的原因。本研究旨在评估肌肉减少症患者上肢肌肉质量（握力/上肢肌肉量）与膝关节骨关节炎之间的关系，并确定与肌肉减少症相关的因素。纳入了2019年6月至2021年11月期间在福井县若狭町响应公开筛查号召的老年人。分析包括433名参与者（304名女性，年龄76.0±7.1岁）。检查（依次）包括基本访谈、身体功能测量、身体成分测量和结果解释。67例患者存在肌肉减少症。二项式逻辑回归分析显示，年龄、上肢肌肉质量评分和膝关节骨关节炎是肌肉减少症的独立因素。肌肉减少症与上肢肌肉质量关系的受试者工作特征分析显示，男性曲线下面积为0.806（95%置信区间：0.658 - 0.953）（截断值，14.3 kg/kg），女性为0.849（95%置信区间：0.858 - 0.968；截断值，14.0 kg/kg）。总之，年龄、上肢肌肉质量和膝关节骨关节炎是肌肉减少症的独立因素。我们证明上肢肌肉质量在检测男性和女性肌肉减少症方面具有良好的准确性。
