Merimi Ihssane, Zinoune Lamyae, Bazid Zakaria, Ismaili Nabila, Elouafi Noha
Faculty of Medicine and Pharmacy, Mohammed I University, Oujda, Morocco.
Department of Cardiology, Mohammed VI University Hospital/Mohammed I University, Oujda, Morocco.
Radiol Case Rep. 2024 Sep 19;19(12):6047-6052. doi: 10.1016/j.radcr.2024.08.080. eCollection 2024 Dec.
Antiphospholipid syndrome (APS) is characterized by hypercoagulability, manifesting as venous or arterial thrombosis, and pregnancy-related complications, such as fetal loss, pre-eclampsia, and eclampsia. These conditions occur in the presence of antiphospholipid antibodies (aPL), including anticardiolipin antibodies (aCL) and/or a positive lupus anticoagulant (LA) test. Antiphospholipid syndrome (APS) can manifest as a primary, isolated condition or be associated with connective tissue diseases, such as systemic lupus erythematosus (SLE). The cardiac system is one of the main target organs affected by APS. This report describes a rare clinical case involving a young woman with a history of recurrent miscarriages, who presented with cardiac complications, including severe mitral regurgitation and Spontaneous coronary artery dissection. Etiological assessment identified antiphospholipid antibody syndrome as the underlying cause. The multidisciplinary management plan included initiating therapeutic-dose anticoagulation, followed by referring the patient for potential mitral valve replacement surgery.
抗磷脂综合征（APS）的特征是高凝状态，表现为静脉或动脉血栓形成，以及与妊娠相关的并发症，如胎儿丢失、先兆子痫和子痫。这些情况发生在存在抗磷脂抗体（aPL）的情况下，包括抗心磷脂抗体（aCL）和/或狼疮抗凝物（LA）试验阳性。抗磷脂综合征（APS）可表现为原发性、孤立性疾病，或与结缔组织疾病相关，如系统性红斑狼疮（SLE）。心脏系统是受APS影响的主要靶器官之一。本报告描述了一例罕见的临床病例，一名有反复流产病史的年轻女性出现心脏并发症，包括严重二尖瓣反流和自发性冠状动脉夹层。病因评估确定抗磷脂抗体综合征为根本原因。多学科管理计划包括开始治疗剂量的抗凝治疗，随后将患者转诊进行潜在的二尖瓣置换手术。
