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凝血障碍对胃肠道健康的影响:抗磷脂综合征和因子V莱顿突变导致血栓形成引起肠缺血的病例报告

The Impact of Clotting Disorders on Gastrointestinal Health: A Case Report of Bowel Ischemia Due to Thrombus Formation in Antiphospholipid Syndrome and Factor V Leiden.

作者信息

Honeini Rawan, Honeini Razan, Abughazal Mahmoud, Ali Noor, Hulo Mohammad

机构信息

Emergency Medicine, United Lincolnshire Hospitals Trust, Boston, GBR.

Medicine, Lebanese American University School of Medicine, Beirut, LBN.

出版信息

Cureus. 2025 Apr 1;17(4):e81556. doi: 10.7759/cureus.81556. eCollection 2025 Apr.

DOI:10.7759/cureus.81556
PMID:40313431
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12044583/
Abstract

Antiphospholipid syndrome and Factor V Leiden are well-recognized hypercoagulable disorders associated with an increased risk of thrombosis in major vascular structures. One of the most severe complications is thrombosis of the superior mesenteric vein and its branches, which can lead to impaired blood flow and bowel ischemia. This report presents the case of a 49-year-old woman with underlying hypercoagulable conditions who initially presented with nonspecific gastrointestinal symptoms and unremarkable laboratory findings, ultimately diagnosed with mesenteric venous thrombosis. The case highlights the importance of maintaining a high index of clinical suspicion, facilitating early diagnosis, and ensuring timely intervention to prevent life-threatening complications.

摘要

抗磷脂综合征和因子V莱顿突变是公认的高凝性疾病,与主要血管结构中血栓形成风险增加相关。最严重的并发症之一是肠系膜上静脉及其分支的血栓形成,这可能导致血流受损和肠缺血。本报告介绍了一名49岁患有潜在高凝状态的女性病例,该患者最初表现为非特异性胃肠道症状且实验室检查结果无异常,最终被诊断为肠系膜静脉血栓形成。该病例强调了保持高度临床怀疑、促进早期诊断以及确保及时干预以预防危及生命并发症的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa6/12044583/c5663169e99c/cureus-0017-00000081556-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa6/12044583/3a0f080ce7cf/cureus-0017-00000081556-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa6/12044583/c5663169e99c/cureus-0017-00000081556-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa6/12044583/3a0f080ce7cf/cureus-0017-00000081556-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6aa6/12044583/c5663169e99c/cureus-0017-00000081556-i02.jpg

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本文引用的文献

1
Spontaneous coronary artery dissection and valvular disease revealing an antiphospholipid syndrome in a young woman: Case report.一名年轻女性因自发性冠状动脉夹层和瓣膜疾病确诊抗磷脂综合征:病例报告
Radiol Case Rep. 2024 Sep 19;19(12):6047-6052. doi: 10.1016/j.radcr.2024.08.080. eCollection 2024 Dec.
2
Homozygous Factor V Leiden presenting as irreversible chronic colon ischemia resulting from inferior mesenteric vein thrombosis.杂合子因子 V Leiden 表现为不可逆的慢性结肠缺血,由肠系膜下静脉血栓形成引起。
Clin J Gastroenterol. 2021 Aug;14(4):1142-1146. doi: 10.1007/s12328-021-01440-4. Epub 2021 May 18.
3
Antiphospholipid syndrome: a clinical review.
抗磷脂综合征:临床综述。
Med J Aust. 2019 Aug;211(4):184-188. doi: 10.5694/mja2.50262. Epub 2019 Jul 4.
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Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report.抗栓治疗 VTE 疾病:CHEST 指南和专家小组报告。
Chest. 2016 Feb;149(2):315-352. doi: 10.1016/j.chest.2015.11.026. Epub 2016 Jan 7.
5
Treatment of Thrombotic Antiphospholipid Syndrome: The Rationale of Current Management-An Insight into Future Approaches.血栓性抗磷脂综合征的治疗:当前管理的原理——对未来方法的深入了解。
J Immunol Res. 2015;2015:951424. doi: 10.1155/2015/951424. Epub 2015 May 5.
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Mesenteric venous thrombosis.肠系膜静脉血栓形成
J Clin Exp Hepatol. 2014 Sep;4(3):257-63. doi: 10.1016/j.jceh.2014.03.052. Epub 2014 Apr 13.
7
Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients.抗磷脂综合征 10 年期间的发病率和死亡率:1000 例患者的多中心前瞻性研究。
Ann Rheum Dis. 2015 Jun;74(6):1011-8. doi: 10.1136/annrheumdis-2013-204838. Epub 2014 Jan 24.
8
Mesenteric venous thrombosis.肠系膜静脉血栓形成。
Mayo Clin Proc. 2013 Mar;88(3):285-94. doi: 10.1016/j.mayocp.2013.01.012. Epub 2013 Feb 27.
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Mesenteric venous thrombosis.肠系膜静脉血栓形成。
Vasc Med. 2010 Oct;15(5):407-18. doi: 10.1177/1358863X10379673.
10
Epidemiology of mesenteric vascular disease: clinical implications.肠系膜血管疾病的流行病学:临床意义。
Semin Vasc Surg. 2010 Mar;23(1):4-8. doi: 10.1053/j.semvascsurg.2009.12.001.